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Anti-Aβ3-10 monoclonal antibody 7B8 improves cognitive function and protects the blood-brain barrier in APP/PS1 mice by regulating the HMGB-1/RAGE/NF-κB pathway.

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Title: Anti-Aβ3-10 monoclonal antibody 7B8 improves cognitive function and protects the blood-brain barrier in APP/PS1 mice by regulating the HMGB-1/RAGE/NF-κB pathway.
Authors: You J; Department of Neurology and Neuroscience, Shenyang First People's Hospital, Shenyang Brain Institute, Shenyang, Liaoning, China., Liu Q; Department of Neurology, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China., Li X; Department of Neurology, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Source: Frontiers in immunology [Front Immunol] 2026 Apr 30; Vol. 17, pp. 1781351. Date of Electronic Publication: 2026 Apr 30 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Anti-Aβ3-10 monoclonal antibody 7B8 improves cognitive function and protects the blood-brain barrier in APP/PS1 mice by regulating the HMGB-1/RAGE/NF-κB pathway.
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  Data: <searchLink fieldCode="AU" term="%22You+J%22">You J</searchLink>; Department of Neurology and Neuroscience, Shenyang First People's Hospital, Shenyang Brain Institute, Shenyang, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; Department of Neurology, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Neurology, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 Apr 30; Vol. 17, pp. 1781351. <i>Date of Electronic Publication: </i>2026 Apr 30 (<i>Print Publication: </i>2026).
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        Value: 10.3389/fimmu.2026.1781351
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      – TitleFull: Anti-Aβ3-10 monoclonal antibody 7B8 improves cognitive function and protects the blood-brain barrier in APP/PS1 mice by regulating the HMGB-1/RAGE/NF-κB pathway.
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              Text: 2026 Apr 30
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