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Brain endothelial Gαq/11 signalling in cerebrovascular function and cognition of aged mice.

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Title: Brain endothelial Gαq/11 signalling in cerebrovascular function and cognition of aged mice.
Authors: Spyropoulos D; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany., Kleindienst L; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany., Ehrich P; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany., Ziemens D; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany., Natsagdorj R; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany., Noll N; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany., Hansen CE; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany., Curley GA; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany., Gutt AS; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany., Menyhárt Á; Hungarian Centre of Excellence for Molecular Medicine - University of Szeged, Cerebral Blood Flow and Metabolism Research Group, Szeged, Hungary; Department of Cell Biology and Molecular Medicine, Albert Szent-Györgyi Medical School and Faculty of Science and Informatics, University of Szeged, Szeged, Hungary., Sedlacik J; Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ludewig P; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Lembrich B; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany., Özorhan Ü; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany., Kostenis E; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Germany., Fiehler J; Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hüttmann G; Institute of Biomedical Optics, University of Lübeck, Lübeck, Germany; German Center of Lung Research (DZL), Lübeck, Germany., Longden TA; Department of Physiology, School of Medicine, University of Maryland, Baltimore, USA., Nogueiras R; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Prevot V; University of Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, DISTALZ, EGID, Lille, France., Müller-Fielitz H; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany., Offermanns S; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Wettschureck N; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Farkas E; Hungarian Centre of Excellence for Molecular Medicine - University of Szeged, Cerebral Blood Flow and Metabolism Research Group, Szeged, Hungary; Department of Cell Biology and Molecular Medicine, Albert Szent-Györgyi Medical School and Faculty of Science and Informatics, University of Szeged, Szeged, Hungary., Schwaninger M; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany., Wenzel J; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany. Electronic address: Jan.wenzel@uni-luebeck.de.
Source: EBioMedicine [EBioMedicine] 2026 Jun; Vol. 128, pp. 106283. Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
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  Data: Brain endothelial Gα<subscript>q/11</subscript> signalling in cerebrovascular function and cognition of aged mice.
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  Data: <searchLink fieldCode="AU" term="%22Spyropoulos+D%22">Spyropoulos D</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Kleindienst+L%22">Kleindienst L</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Ehrich+P%22">Ehrich P</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Ziemens+D%22">Ziemens D</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Natsagdorj+R%22">Natsagdorj R</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Noll+N%22">Noll N</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Hansen+CE%22">Hansen CE</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Curley+GA%22">Curley GA</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Gutt+AS%22">Gutt AS</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Menyhárt+Á%22">Menyhárt Á</searchLink>; Hungarian Centre of Excellence for Molecular Medicine - University of Szeged, Cerebral Blood Flow and Metabolism Research Group, Szeged, Hungary; Department of Cell Biology and Molecular Medicine, Albert Szent-Györgyi Medical School and Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Sedlacik+J%22">Sedlacik J</searchLink>; Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ludewig+P%22">Ludewig P</searchLink>; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lembrich+B%22">Lembrich B</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Özorhan+Ü%22">Özorhan Ü</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Kostenis+E%22">Kostenis E</searchLink>; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Fiehler+J%22">Fiehler J</searchLink>; Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hüttmann+G%22">Hüttmann G</searchLink>; Institute of Biomedical Optics, University of Lübeck, Lübeck, Germany; German Center of Lung Research (DZL), Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Longden+TA%22">Longden TA</searchLink>; Department of Physiology, School of Medicine, University of Maryland, Baltimore, USA.<br /><searchLink fieldCode="AU" term="%22Nogueiras+R%22">Nogueiras R</searchLink>; Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Prevot+V%22">Prevot V</searchLink>; University of Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, DISTALZ, EGID, Lille, France.<br /><searchLink fieldCode="AU" term="%22Müller-Fielitz+H%22">Müller-Fielitz H</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Offermanns+S%22">Offermanns S</searchLink>; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Wettschureck+N%22">Wettschureck N</searchLink>; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Farkas+E%22">Farkas E</searchLink>; Hungarian Centre of Excellence for Molecular Medicine - University of Szeged, Cerebral Blood Flow and Metabolism Research Group, Szeged, Hungary; Department of Cell Biology and Molecular Medicine, Albert Szent-Györgyi Medical School and Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Schwaninger+M%22">Schwaninger M</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Wenzel+J%22">Wenzel J</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site North, Lübeck, Germany. Electronic address: Jan.wenzel@uni-luebeck.de.
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