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From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy.

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Title: From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy.
Authors: Roy N; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Tissue and Tumor Microenvironments Lab, Cancer Discovery and Regenerative Medicine Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Liu H; Tissue and Tumor Microenvironments Lab, Cancer Discovery and Regenerative Medicine Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Horenberg AL; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Pathak AP; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA.; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Chen J; Tissue and Tumor Microenvironments Lab, Cancer Discovery and Regenerative Medicine Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China., Ramasamy SK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Multidisciplinary Institute of Ageing (MIA-Portugal), University of Coimbra, Coimbra, Portugal., Cohen-Solal M; Department of Rheumatology and Reference Center for Rare Bone Diseases, Hospital Lariboisière, Paris, France.; Inserm U1132 Bioscar, Université Paris Cité, Centre Viggo Petersen Hôpital Lariboisière, APHP.Nord, Paris, France., Bozec A; Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany., Grayson WL; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA.; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA.; Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA., Kusumbe AP; Tissue and Tumor Microenvironments Lab, Cancer Discovery and Regenerative Medicine Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. anjali.pkusumbe@ntu.edu.sg.; Multidisciplinary Institute of Ageing (MIA-Portugal), University of Coimbra, Coimbra, Portugal. anjali.pkusumbe@ntu.edu.sg.
Source: Bone research [Bone Res] 2026 May 18; Vol. 14 (1). Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article; Review
Journal Info: Publisher: West China School of Stomatology, Sichuan University Country of Publication: China NLM ID: 101608652 Publication Model: Electronic Cited Medium: Print ISSN: 2095-4700 (Print) Linking ISSN: 20954700 NLM ISO Abbreviation: Bone Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy.
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  Data: <searchLink fieldCode="AU" term="%22Roy+N%22">Roy N</searchLink>; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Tissue and Tumor Microenvironments Lab, Cancer Discovery and Regenerative Medicine Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Tissue and Tumor Microenvironments Lab, Cancer Discovery and Regenerative Medicine Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Horenberg+AL%22">Horenberg AL</searchLink>; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Pathak+AP%22">Pathak AP</searchLink>; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA.; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Tissue and Tumor Microenvironments Lab, Cancer Discovery and Regenerative Medicine Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Ramasamy+SK%22">Ramasamy SK</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Multidisciplinary Institute of Ageing (MIA-Portugal), University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Cohen-Solal+M%22">Cohen-Solal M</searchLink>; Department of Rheumatology and Reference Center for Rare Bone Diseases, Hospital Lariboisière, Paris, France.; Inserm U1132 Bioscar, Université Paris Cité, Centre Viggo Petersen Hôpital Lariboisière, APHP.Nord, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bozec+A%22">Bozec A</searchLink>; Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Grayson+WL%22">Grayson WL</searchLink>; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA.; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA.; Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kusumbe+AP%22">Kusumbe AP</searchLink>; Tissue and Tumor Microenvironments Lab, Cancer Discovery and Regenerative Medicine Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. anjali.pkusumbe@ntu.edu.sg.; Multidisciplinary Institute of Ageing (MIA-Portugal), University of Coimbra, Coimbra, Portugal. anjali.pkusumbe@ntu.edu.sg.
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        Value: 10.1038/s41413-026-00543-3
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        Text: English
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              Text: 2026 May 18
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