Cardiolipin preserves Treg metabolic fitness and immune homeostasis in the gut.

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Title: Cardiolipin preserves Treg metabolic fitness and immune homeostasis in the gut.
Authors: Regina A; Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Solagna F; Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Max Planck Institute for Immunobiology and Epigenetics, Freiburg im Breisgau, Germany., Estrada MS; Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Jacobs MME; Max Planck Institute for Immunobiology and Epigenetics, Freiburg im Breisgau, Germany., Martinez-Martinez D; Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany.; Institute of Clinical Sciences, Imperial College London, London, UK., Georgomanolis T; Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Institute for Metabolomics in Ageing, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Alibashikj I; Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Gjurgji S; Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Pearson C; Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK., Chang D; Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK., Moschandrea C; Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Institute for Metabolomics in Ageing, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Aparisi AS; Centro de Biologia Molecular Severo Ochoa (CBM), CSIC-UAM, and Institute for Molecular Biology-IUBM, Universidad Autónoma de Madrid, Madrid, Spain., Crespo E; Roger Williams Institute of Liver Studies, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London University, and King's College Hospital, London, UK., Buechel J; Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Schneider F; Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Institute for Metabolomics in Ageing, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Trojahn L; Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Department Cell Biology of the Skin, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Pfelzer P; Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Popovic M; Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Institute for Mitochondrial Diseases in Ageing, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Potenza E; Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Kabat AM; Max Planck Institute for Immunobiology and Epigenetics, Freiburg im Breisgau, Germany., Niessen C; Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Department Cell Biology of the Skin, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Amulic B; University of Bristol, Bristol, UK., Safinia N; Roger Williams Institute of Liver Studies, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London University, and King's College Hospital, London, UK., Cogliati S; Centro de Biologia Molecular Severo Ochoa (CBM), CSIC-UAM, and Institute for Molecular Biology-IUBM, Universidad Autónoma de Madrid, Madrid, Spain., Sanin DE; Department of Oncology, Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Villa M; Max Planck Institute for Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.; Division of Rheumatology and Immunology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Pearce EJ; Max Planck Institute for Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.; Department of Oncology, Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Frezza C; Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Institute for Metabolomics in Ageing, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Pearce EL; Max Planck Institute for Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.; Department of Oncology, Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Cabreiro F; Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Institute of Clinical Sciences, Imperial College London, London, UK., Powrie F; Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK., Corrado M; Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany. mcorrado@uni-koeln.de.; Cologne Excellence Cluster on Aging and Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany. mcorrado@uni-koeln.de.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. mcorrado@uni-koeln.de.; Max Planck Institute for Immunobiology and Epigenetics, Freiburg im Breisgau, Germany. mcorrado@uni-koeln.de.
Source: Nature metabolism [Nat Metab] 2026 Jun; Vol. 8 (6), pp. 1368-1389. Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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