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Genome-wide variation in cell-free DNA end motif entropy predicts immunotherapy response in head and neck cancer.

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Title: Genome-wide variation in cell-free DNA end motif entropy predicts immunotherapy response in head and neck cancer.
Authors: Bandaru R; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, United States of America., Fu H; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, United States of America., Zheng H; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America., Liang J; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, United States of America., Wang L; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, United States of America., Gulati S; Division of Hematology/Oncology, University of Cincinnati, Cincinnati, United States of America., Hinrichs BH; Department of Pathology, University of Cincinnati, Cincinnati, United States of America., Teng M; Department of Biostatistics & Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, United States of America., Zhang B; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America., Kocherginsky M; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, United States of America., Lin DC; Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistr, University of Southern California, Los Angeles, United States of America., Hildeman DA; Division of Immunobiology, University of Cincinnati College of Medicine, Cincinnati, United States of America., Worden FP; University of Michigan Cancer Center, Ann Arbor, United States of America., Old MO; Department of Otolaryngology, Ohio State University, Columbus, United States of America., Dunlap NE; Department of Radiation Oncology, University of Louisville, Louisville, United States of America., Kaczmar JM; Division of Hematology/Oncology, Medical University of South Carolina, Charleston, United States of America., Gillison ML; Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, United States of America., El-Gamal D; Division of Hematology/Oncology, University of Cincinnati, Cincinnati, United States of America., Wise Draper T; Division of Hematology/Oncology, University of Cincinnati, Cincinnati, United States of America., Liu Y; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, United States of America.
Source: The Journal of clinical investigation [J Clin Invest] 2026 May 19. Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genome-wide variation in cell-free DNA end motif entropy predicts immunotherapy response in head and neck cancer.
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  Data: <searchLink fieldCode="AU" term="%22Bandaru+R%22">Bandaru R</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, United States of America.<br /><searchLink fieldCode="AU" term="%22Fu+H%22">Fu H</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, United States of America.<br /><searchLink fieldCode="AU" term="%22Zheng+H%22">Zheng H</searchLink>; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America.<br /><searchLink fieldCode="AU" term="%22Liang+J%22">Liang J</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, United States of America.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, United States of America.<br /><searchLink fieldCode="AU" term="%22Gulati+S%22">Gulati S</searchLink>; Division of Hematology/Oncology, University of Cincinnati, Cincinnati, United States of America.<br /><searchLink fieldCode="AU" term="%22Hinrichs+BH%22">Hinrichs BH</searchLink>; Department of Pathology, University of Cincinnati, Cincinnati, United States of America.<br /><searchLink fieldCode="AU" term="%22Teng+M%22">Teng M</searchLink>; Department of Biostatistics & Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, United States of America.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America.<br /><searchLink fieldCode="AU" term="%22Kocherginsky+M%22">Kocherginsky M</searchLink>; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, United States of America.<br /><searchLink fieldCode="AU" term="%22Lin+DC%22">Lin DC</searchLink>; Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistr, University of Southern California, Los Angeles, United States of America.<br /><searchLink fieldCode="AU" term="%22Hildeman+DA%22">Hildeman DA</searchLink>; Division of Immunobiology, University of Cincinnati College of Medicine, Cincinnati, United States of America.<br /><searchLink fieldCode="AU" term="%22Worden+FP%22">Worden FP</searchLink>; University of Michigan Cancer Center, Ann Arbor, United States of America.<br /><searchLink fieldCode="AU" term="%22Old+MO%22">Old MO</searchLink>; Department of Otolaryngology, Ohio State University, Columbus, United States of America.<br /><searchLink fieldCode="AU" term="%22Dunlap+NE%22">Dunlap NE</searchLink>; Department of Radiation Oncology, University of Louisville, Louisville, United States of America.<br /><searchLink fieldCode="AU" term="%22Kaczmar+JM%22">Kaczmar JM</searchLink>; Division of Hematology/Oncology, Medical University of South Carolina, Charleston, United States of America.<br /><searchLink fieldCode="AU" term="%22Gillison+ML%22">Gillison ML</searchLink>; Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, United States of America.<br /><searchLink fieldCode="AU" term="%22El-Gamal+D%22">El-Gamal D</searchLink>; Division of Hematology/Oncology, University of Cincinnati, Cincinnati, United States of America.<br /><searchLink fieldCode="AU" term="%22Wise+Draper+T%22">Wise Draper T</searchLink>; Division of Hematology/Oncology, University of Cincinnati, Cincinnati, United States of America.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, United States of America.
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