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Transcription start site heterogeneity controls MDA5 sensing of unspliced HIV-1 RNAs.

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Title: Transcription start site heterogeneity controls MDA5 sensing of unspliced HIV-1 RNAs.
Authors: Hughes IK; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118., Kharytonchyk S; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109., Ramaswamy S; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118., Jalloh S; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118., Hood JB; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118., He X; Department of Medicine, Section of Infectious Diseases, Boston Medical Center, Boston, MA 02118., Henderson AJ; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118.; Department of Medicine, Section of Infectious Diseases, Boston Medical Center, Boston, MA 02118., Akiyama H; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118., Telesnitsky A; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109., Gummuluru S; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 May 26; Vol. 123 (21), pp. e2522948123. Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Hughes+IK%22">Hughes IK</searchLink>; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118.<br /><searchLink fieldCode="AU" term="%22Kharytonchyk+S%22">Kharytonchyk S</searchLink>; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.<br /><searchLink fieldCode="AU" term="%22Ramaswamy+S%22">Ramaswamy S</searchLink>; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118.<br /><searchLink fieldCode="AU" term="%22Jalloh+S%22">Jalloh S</searchLink>; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118.<br /><searchLink fieldCode="AU" term="%22Hood+JB%22">Hood JB</searchLink>; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118.<br /><searchLink fieldCode="AU" term="%22He+X%22">He X</searchLink>; Department of Medicine, Section of Infectious Diseases, Boston Medical Center, Boston, MA 02118.<br /><searchLink fieldCode="AU" term="%22Henderson+AJ%22">Henderson AJ</searchLink>; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118.; Department of Medicine, Section of Infectious Diseases, Boston Medical Center, Boston, MA 02118.<br /><searchLink fieldCode="AU" term="%22Akiyama+H%22">Akiyama H</searchLink>; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118.<br /><searchLink fieldCode="AU" term="%22Telesnitsky+A%22">Telesnitsky A</searchLink>; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.<br /><searchLink fieldCode="AU" term="%22Gummuluru+S%22">Gummuluru S</searchLink>; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 May 26; Vol. 123 (21), pp. e2522948123. <i>Date of Electronic Publication: </i>2026 May 19.
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