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Novelty exploration-activated ensemble in the lateral hypothalamus confers analgesic and anxiolytic effects.

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Title: Novelty exploration-activated ensemble in the lateral hypothalamus confers analgesic and anxiolytic effects.
Authors: Jia T; School of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, China.; Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Peng YT; School of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, China., Sun YL; School of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, China., Yin C; School of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, China., Gu X; School of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, China., Yang L; Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhang S; Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhangsong1031@163.com., Cao JL; School of Anesthesiology, Xuzhou Medical University, Xuzhou, China. Cao0310@aliyun.com.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China. Cao0310@aliyun.com.; Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, China. Cao0310@aliyun.com.; Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. Cao0310@aliyun.com., Xiao C; School of Anesthesiology, Xuzhou Medical University, Xuzhou, China. xchengxj@xzhmu.edu.cn.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China. xchengxj@xzhmu.edu.cn.; Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, China. xchengxj@xzhmu.edu.cn., Zhou C; School of Anesthesiology, Xuzhou Medical University, Xuzhou, China. Chunyi.zhou@xzhmu.edu.cn.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China. Chunyi.zhou@xzhmu.edu.cn.; Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, China. Chunyi.zhou@xzhmu.edu.cn.
Source: Nature communications [Nat Commun] 2026 May 19; Vol. 17 (1). Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Jia+T%22">Jia T</searchLink>; School of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, China.; Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Peng+YT%22">Peng YT</searchLink>; School of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, China.<br /><searchLink fieldCode="AU" term="%22Sun+YL%22">Sun YL</searchLink>; School of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, China.<br /><searchLink fieldCode="AU" term="%22Yin+C%22">Yin C</searchLink>; School of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, China.<br /><searchLink fieldCode="AU" term="%22Gu+X%22">Gu X</searchLink>; School of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China.; Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, China.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhangsong1031@163.com.<br /><searchLink fieldCode="AU" term="%22Cao+JL%22">Cao JL</searchLink>; School of Anesthesiology, Xuzhou Medical University, Xuzhou, China. Cao0310@aliyun.com.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China. Cao0310@aliyun.com.; Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, China. Cao0310@aliyun.com.; Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. Cao0310@aliyun.com.<br /><searchLink fieldCode="AU" term="%22Xiao+C%22">Xiao C</searchLink>; School of Anesthesiology, Xuzhou Medical University, Xuzhou, China. xchengxj@xzhmu.edu.cn.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China. xchengxj@xzhmu.edu.cn.; Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, China. xchengxj@xzhmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhou+C%22">Zhou C</searchLink>; School of Anesthesiology, Xuzhou Medical University, Xuzhou, China. Chunyi.zhou@xzhmu.edu.cn.; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China. Chunyi.zhou@xzhmu.edu.cn.; Jiangsu Province Key Laboratory of Anesthesiology and Brain Science, Xuzhou Medical University, Xuzhou, China. Chunyi.zhou@xzhmu.edu.cn.
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        Value: 10.1038/s41467-026-73205-x
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              Text: 2026 May 19
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