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The rise and fall of SARM1 base-exchange inhibitors.

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Title: The rise and fall of SARM1 base-exchange inhibitors.
Authors: Lundbäck T; Assays, Profiling & Cell Sciences, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden. thomas.lundback@astrazeneca.com., Chandrasekar V; Assays, Profiling & Cell Sciences, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Gu C; Assays, Profiling & Cell Sciences, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Ju H; Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK., McAdam R; Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK., Palomero M; Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK., Sader K; Protein Sciences, Structural Biology, and Biophysics, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Peter B; Protein Sciences, Structural Biology, and Biophysics, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Wissler L; Protein Sciences, Structural Biology, and Biophysics, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Nevin P; Assays, Profiling & Cell Sciences, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Foster E; Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK., Jamier T; Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK., Manjappa P; Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK., Johansson C; Protein Sciences, Structural Biology, and Biophysics, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Sandmark J; Protein Sciences, Structural Biology, and Biophysics, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Ding M; Assays, Profiling & Cell Sciences, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Persson-Kry A; Centre for Genomics Research, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Mitra S; Centre for Genomics Research, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Munise Satir T; Centre for Genomics Research, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Bilican B; Centre for Genomics Research, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Messa M; Centre for Genomics Research, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Fraser G; Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK., Linley J; Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK., Plant H; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Moore R; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Seifert T; Compound Synthesis & Management, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Lerche M; Pharmaceutical Sciences, Biopharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Raynochek C; Protein Sciences, Structural Biology, and Biophysics, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Nilsson E; Protein Sciences, Structural Biology, and Biophysics, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Majbour N; Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK., Lucey R; Spatial & Quantitative Omics, Discovery Bioanalysis, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK., Maia de Oliveira T; Protein Sciences, Structural Biology, and Biophysics, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Wang Q; Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Boston, MA, USA., Chessell I; Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK., Breccia P; Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK., Jarvis R; Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK. rebecca.jarvis@astrazeneca.com.
Source: Communications chemistry [Commun Chem] 2026 May 19; Vol. 9 (1). Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101725670 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3669 (Electronic) Linking ISSN: 23993669 NLM ISO Abbreviation: Commun Chem Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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Protein Sciences, Structural Biology, and Biophysics, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chessell+I%22">Chessell I</searchLink>; Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Breccia+P%22">Breccia P</searchLink>; Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Jarvis+R%22">Jarvis R</searchLink>; Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK. rebecca.jarvis@astrazeneca.com.
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