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De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection.

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Title: De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection.
Authors: Sanhueza S; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile., Cabrera C; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile., Quiroga R; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile., Antilef B; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile., Muñoz C; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile.; Facultad de Odontología, Universidad San Sebastián, Concepción, Chile., Vera A; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile., Cartes R; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile.; Facultad de Derecho y ciencias sociales, Universidad San Sebastián, Concepción, Chile., Lamperti L; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile., Guzmán-Gutiérrez E; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile., Aguayo C; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile., Ormazábal V; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile., Hernández MA; Division of Biotechnology, MELISA Institute, San Pedro de la Paz, Chile., Lastra J; Medicine Department, Hospital Guillermo Grant Benavente and Medicine Faculty, University of Concepcion, Concepcion, Chile., Riffo B; Prevegen Laboratory, Concepcion, Chile., Cerda G; Advanced Microscopy Center, University of Concepcion, Concepcion, Chile., Ferrada L; Advanced Microscopy Center, University of Concepcion, Concepcion, Chile., De Gonzalo-Calvo D; Clinical and Molecular Phenotyping, Biomedical Research Institute of Lleida - Dr. Pifarré Foundation, IRBLleida, Lleida, Spain.; Centro de Investigación Biomédica en Red of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain., García-Hidalgo MC; Clinical and Molecular Phenotyping, Biomedical Research Institute of Lleida - Dr. Pifarré Foundation, IRBLleida, Lleida, Spain.; Centro de Investigación Biomédica en Red of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain., Henríquez M; Magíster en Ciencias de la Motricidad Humana, Universidad Adventista de Chile, Chillán, Chile.; Escuela de Kinesiología, Facultad de Salud, Universidad Santo Tomás, Los Ángeles, Chile.; Departamento de Enfermedades Respiratorias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile., Barría MI; Facultad de Medicina, Universidad San Sebastián, Puerto Montt, Chile., Verdugo RA; Departamento de Oncología Básico Clínico and Centro para la Prevención y el Control del Cáncer (CeCAN), Facultad de Medicina, Universidad de Chile, Santiago, Chile., Colombo A; Biobanco de tejidos y fluidos, Universidad de Chile, Santiago, Chile., Labarca G; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile.; Departamento de Enfermedades Respiratorias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.; Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.; Internal Medicine, Complejo Asistencial Dr. Víctor Ríos Ruiz, Los Ángeles, Chile., Nova-Lamperti E; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile.
Source: Frontiers in immunology [Front Immunol] 2026 May 04; Vol. 17, pp. 1787799. Date of Electronic Publication: 2026 May 04 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection.
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  Data: <searchLink fieldCode="AU" term="%22Sanhueza+S%22">Sanhueza S</searchLink>; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile.<br /><searchLink fieldCode="AU" term="%22Cabrera+C%22">Cabrera C</searchLink>; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile.<br /><searchLink fieldCode="AU" term="%22Quiroga+R%22">Quiroga R</searchLink>; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile.<br /><searchLink fieldCode="AU" term="%22Antilef+B%22">Antilef B</searchLink>; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile.<br /><searchLink fieldCode="AU" term="%22Muñoz+C%22">Muñoz C</searchLink>; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile.; Facultad de Odontología, Universidad San Sebastián, Concepción, Chile.<br /><searchLink fieldCode="AU" term="%22Vera+A%22">Vera A</searchLink>; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile.<br /><searchLink fieldCode="AU" term="%22Cartes+R%22">Cartes R</searchLink>; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile.; Facultad de Derecho y ciencias sociales, Universidad San Sebastián, Concepción, Chile.<br /><searchLink fieldCode="AU" term="%22Lamperti+L%22">Lamperti L</searchLink>; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile.<br /><searchLink fieldCode="AU" term="%22Guzmán-Gutiérrez+E%22">Guzmán-Gutiérrez E</searchLink>; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile.<br /><searchLink fieldCode="AU" term="%22Aguayo+C%22">Aguayo C</searchLink>; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile.<br /><searchLink fieldCode="AU" term="%22Ormazábal+V%22">Ormazábal V</searchLink>; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile.<br /><searchLink fieldCode="AU" term="%22Hernández+MA%22">Hernández MA</searchLink>; Division of Biotechnology, MELISA Institute, San Pedro de la Paz, Chile.<br /><searchLink fieldCode="AU" term="%22Lastra+J%22">Lastra J</searchLink>; Medicine Department, Hospital Guillermo Grant Benavente and Medicine Faculty, University of Concepcion, Concepcion, Chile.<br /><searchLink fieldCode="AU" term="%22Riffo+B%22">Riffo B</searchLink>; Prevegen Laboratory, Concepcion, Chile.<br /><searchLink fieldCode="AU" term="%22Cerda+G%22">Cerda G</searchLink>; Advanced Microscopy Center, University of Concepcion, Concepcion, Chile.<br /><searchLink fieldCode="AU" term="%22Ferrada+L%22">Ferrada L</searchLink>; Advanced Microscopy Center, University of Concepcion, Concepcion, Chile.<br /><searchLink fieldCode="AU" term="%22De+Gonzalo-Calvo+D%22">De Gonzalo-Calvo D</searchLink>; Clinical and Molecular Phenotyping, Biomedical Research Institute of Lleida - Dr. Pifarré Foundation, IRBLleida, Lleida, Spain.; Centro de Investigación Biomédica en Red of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22García-Hidalgo+MC%22">García-Hidalgo MC</searchLink>; Clinical and Molecular Phenotyping, Biomedical Research Institute of Lleida - Dr. Pifarré Foundation, IRBLleida, Lleida, Spain.; Centro de Investigación Biomédica en Red of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Henríquez+M%22">Henríquez M</searchLink>; Magíster en Ciencias de la Motricidad Humana, Universidad Adventista de Chile, Chillán, Chile.; Escuela de Kinesiología, Facultad de Salud, Universidad Santo Tomás, Los Ángeles, Chile.; Departamento de Enfermedades Respiratorias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Barría+MI%22">Barría MI</searchLink>; Facultad de Medicina, Universidad San Sebastián, Puerto Montt, Chile.<br /><searchLink fieldCode="AU" term="%22Verdugo+RA%22">Verdugo RA</searchLink>; Departamento de Oncología Básico Clínico and Centro para la Prevención y el Control del Cáncer (CeCAN), Facultad de Medicina, Universidad de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Colombo+A%22">Colombo A</searchLink>; Biobanco de tejidos y fluidos, Universidad de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Labarca+G%22">Labarca G</searchLink>; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile.; Departamento de Enfermedades Respiratorias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.; Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.; Internal Medicine, Complejo Asistencial Dr. Víctor Ríos Ruiz, Los Ángeles, Chile.<br /><searchLink fieldCode="AU" term="%22Nova-Lamperti+E%22">Nova-Lamperti E</searchLink>; Molecular and Translational Immunology laboratory, Department of Clinical Biochemistry and Immunology, Pharmacy Faculty, University of Concepcion, Concepcion, Chile.
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