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Loss-of-Function (G603R) Lrp10 Fails to Downregulate mRNA of Pathologic α-Synuclein and Causes Neurodegeneration of Substantia Nigra Dopaminergic Cells in Parkinson's Disease Knockin Mice.

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Title: Loss-of-Function (G603R) Lrp10 Fails to Downregulate mRNA of Pathologic α-Synuclein and Causes Neurodegeneration of Substantia Nigra Dopaminergic Cells in Parkinson's Disease Knockin Mice.
Authors: Wang HL; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan.; Division of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Healthy Aging Research Center, Chang Gung University College of Medicine, Taoyuan, Taiwan.; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan., Liu SY; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan., Chiu CC; Healthy Aging Research Center, Chang Gung University College of Medicine, Taoyuan, Taiwan.; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Department of Medical Biotechnology and Laboratory Science, Chang Gung University College of Medicine, Taoyuan, Taiwan., Yeh TH; Department of Neurology, Taipei Medical University Hospital, Taipei, Taiwan., Chen WS; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan., Chiu TJ; Graduate Institute of Biomedical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan., Yeh YC; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan., Wu PR; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan., Weng YH; Division of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. yhweng2488@gmail.com.; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. yhweng2488@gmail.com.; College of Medicine, Chang Gung University, Taoyuan, Taiwan. yhweng2488@gmail.com.
Source: Neurochemical research [Neurochem Res] 2026 May 20; Vol. 51 (3). Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article
Journal Info: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7613461 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6903 (Electronic) Linking ISSN: 03643190 NLM ISO Abbreviation: Neurochem Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Loss-of-Function (G603R) Lrp10 Fails to Downregulate mRNA of Pathologic α-Synuclein and Causes Neurodegeneration of Substantia Nigra Dopaminergic Cells in Parkinson's Disease Knockin Mice.
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  Data: <searchLink fieldCode="AU" term="%22Wang+HL%22">Wang HL</searchLink>; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan.; Division of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Healthy Aging Research Center, Chang Gung University College of Medicine, Taoyuan, Taiwan.; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+SY%22">Liu SY</searchLink>; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiu+CC%22">Chiu CC</searchLink>; Healthy Aging Research Center, Chang Gung University College of Medicine, Taoyuan, Taiwan.; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Department of Medical Biotechnology and Laboratory Science, Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+TH%22">Yeh TH</searchLink>; Department of Neurology, Taipei Medical University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+WS%22">Chen WS</searchLink>; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiu+TJ%22">Chiu TJ</searchLink>; Graduate Institute of Biomedical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+YC%22">Yeh YC</searchLink>; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+PR%22">Wu PR</searchLink>; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Weng+YH%22">Weng YH</searchLink>; Division of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. yhweng2488@gmail.com.; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. yhweng2488@gmail.com.; College of Medicine, Chang Gung University, Taoyuan, Taiwan. yhweng2488@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%227613461%22">Neurochemical research</searchLink> [Neurochem Res] 2026 May 20; Vol. 51 (3). <i>Date of Electronic Publication: </i>2026 May 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Kluwer+Academic%2FPlenum+Publishers%22">Kluwer Academic/Plenum Publishers </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7613461 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-6903 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203643190%22">03643190 </searchLink><i>NLM ISO Abbreviation: </i>Neurochem Res <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s11064-026-04762-2
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        Text: English
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      – TitleFull: Loss-of-Function (G603R) Lrp10 Fails to Downregulate mRNA of Pathologic α-Synuclein and Causes Neurodegeneration of Substantia Nigra Dopaminergic Cells in Parkinson's Disease Knockin Mice.
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              M: 05
              Text: 2026 May 20
              Type: published
              Y: 2026
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