Limited Nrf2 activation and heterogeneous thyroidal effects in a 424-compound multi-assay screen call for rigorous testing of purported antioxidant and health-promoting supplements.

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Title: Limited Nrf2 activation and heterogeneous thyroidal effects in a 424-compound multi-assay screen call for rigorous testing of purported antioxidant and health-promoting supplements.
Authors: Psarias G; Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland., Ziros PG; Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland. Electronic address: panos.ziros@chuv.ch., Mageiropoulou A; Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland., Chartoumpekis DV; Division of Endocrinology, School of Medicine, University of Patras, Patras, 26500, Greece., Habeos GI; Division of Endocrinology, School of Medicine, University of Patras, Patras, 26500, Greece., Alomair BM; Department of Internal Medicine, College of Medicine, Jouf University, Aljouf, 04631, Kingdom of Saudi Arabia., Duntas L; Evgenidion Hospital Unit of Endocrinology, Diabetes, and Metabolism, Thyroid Section, National and Kapodistrian University of Athens, Athens, Greece., Trougakos IP; Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Athens, 15784, Greece., Sykiotis GP; Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland. Electronic address: gerasimos.sykiotis@chuv.ch.
Source: Redox biology [Redox Biol] 2026 Jul; Vol. 94, pp. 104222. Date of Electronic Publication: 2026 May 16.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2213-2317
DOI:10.1016/j.redox.2026.104222