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Xanomeline-trospium reverses phencyclidine-induced cognitive deficits through modulation of the gut microbiota-brain axis in mice.

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Title: Xanomeline-trospium reverses phencyclidine-induced cognitive deficits through modulation of the gut microbiota-brain axis in mice.
Authors: Ding X; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.; Neuroscience Research Institute, Zhengzhou University Academy of Medical Sciences, Zhengzhou University, Zhengzhou, 450052, China., Murayama R; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan., Cai Y; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan., Yue Y; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.; Department of Pharmacology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan., Yang JJ; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. yjyangjj@126.com.; Neuroscience Research Institute, Zhengzhou University Academy of Medical Sciences, Zhengzhou University, Zhengzhou, 450052, China. yjyangjj@126.com.; Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. yjyangjj@126.com., Hashimoto K; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan. hashimoto@faculty.chiba-u.jp.; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. hashimoto@faculty.chiba-u.jp.; Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education, Southwest Medical University, Luzhou, 646000, Sichuan, China. hashimoto@faculty.chiba-u.jp.
Source: Translational psychiatry [Transl Psychiatry] 2026 May 20. Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Ding+X%22">Ding X</searchLink>; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.; Neuroscience Research Institute, Zhengzhou University Academy of Medical Sciences, Zhengzhou University, Zhengzhou, 450052, China.<br /><searchLink fieldCode="AU" term="%22Murayama+R%22">Murayama R</searchLink>; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.<br /><searchLink fieldCode="AU" term="%22Yue+Y%22">Yue Y</searchLink>; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.; Department of Pharmacology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.<br /><searchLink fieldCode="AU" term="%22Yang+JJ%22">Yang JJ</searchLink>; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. yjyangjj@126.com.; Neuroscience Research Institute, Zhengzhou University Academy of Medical Sciences, Zhengzhou University, Zhengzhou, 450052, China. yjyangjj@126.com.; Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. yjyangjj@126.com.<br /><searchLink fieldCode="AU" term="%22Hashimoto+K%22">Hashimoto K</searchLink>; Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan. hashimoto@faculty.chiba-u.jp.; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. hashimoto@faculty.chiba-u.jp.; Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education, Southwest Medical University, Luzhou, 646000, Sichuan, China. hashimoto@faculty.chiba-u.jp.
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              Text: 2026 May 20
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