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MesenSistem-EB: systemic haploidentical mesenchymal stem cell therapy in recessive dystrophic epidermolysis bullosa associated with clinical benefits and correlated with MCP1 and sCD40L dynamics.

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Title: MesenSistem-EB: systemic haploidentical mesenchymal stem cell therapy in recessive dystrophic epidermolysis bullosa associated with clinical benefits and correlated with MCP1 and sCD40L dynamics.
Authors: Maseda R; Department of Dermatology, La Paz University Hospital, Madrid, Spain., Arriba MC; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain., Martínez-Santamaría L; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain., Jiménez E; Cell Biology Department, Faculty of Medicine, Complutense University, Madrid, Spain., Herráiz-Gil S; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain., Illera N; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain., Quintana-Castanedo L; Department of Dermatology, La Paz University Hospital, Madrid, Spain., García M; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain., Suárez-Sancho S; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain.; ATMPs Production Unit-GMP Facility, Gregorio Marañón General University Hospital, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., Yáñez R; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain.; Division of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas, Medioambientales, y Tecnológicas (CIEMAT)/Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER-ISCIII), Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz (IIS-FJD), Madrid, Spain., Pérez-Conde I; Department of Dermatology, La Paz University Hospital, Madrid, Spain., Carretero M; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain., Martínez-Queipo M; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, United Kingdom.; National Institute for Health and Care Research (NIHR) Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, United Kingdom., de Paz R; IdiPAZ, Hospital La Paz Insititute for Health Research, La Paz University Hospital, Madrid, Spain., León C; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain., Jiménez-Yuste V; Coagulopathies and Haemostasis Disorders Group, IdiPaz, Hematology and Haemotherapy Unit, La Paz University Hospital, Madrid, Spain., Borobia AM; Clinical Pharmacology Department, IdiPAZ, La Paz University Hospital, School of Medicine, Autonomous University of Madrid, Madrid, Spain., Vicente Á; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain.; Cell Biology Department, Faculty of Medicine, Complutense University, Madrid, Spain.; Stem Cells, Immunity and Cancer Group, Health Research Institute Hospital 12 de Octubre (i+ 12), Madrid, Spain., Lwin SM; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, United Kingdom.; National Institute for Health and Care Research (NIHR) Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, United Kingdom., McGrath JA; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, United Kingdom.; National Institute for Health and Care Research (NIHR) Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, United Kingdom., Fernández-Santos ME; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain.; ATMPs Production Unit-GMP Facility, Gregorio Marañón General University Hospital, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., Butta N; Coagulopathies and Haemostasis Disorders Group, IdiPaz, Hematology and Haemotherapy Unit, La Paz University Hospital, Madrid, Spain., Sacedón R; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain.; Cell Biology Department, Faculty of Medicine, Complutense University, Madrid, Spain., Del Río M; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain., de Lucas R; Department of Dermatology, La Paz University Hospital, Madrid, Spain., Escámez MJ; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain.
Source: Frontiers in immunology [Front Immunol] 2026 May 05; Vol. 17, pp. 1789537. Date of Electronic Publication: 2026 May 05 (Print Publication: 2026).
Publication Type: Journal Article; Clinical Trial, Phase I; Clinical Trial, Phase II; Clinical Trial
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: MesenSistem-EB: systemic haploidentical mesenchymal stem cell therapy in recessive dystrophic epidermolysis bullosa associated with clinical benefits and correlated with MCP1 and sCD40L dynamics.
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  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Maseda+R%22">Maseda R</searchLink>; Department of Dermatology, La Paz University Hospital, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Arriba+MC%22">Arriba MC</searchLink>; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez-Santamaría+L%22">Martínez-Santamaría L</searchLink>; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Jiménez+E%22">Jiménez E</searchLink>; Cell Biology Department, Faculty of Medicine, Complutense University, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Herráiz-Gil+S%22">Herráiz-Gil S</searchLink>; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Illera+N%22">Illera N</searchLink>; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Quintana-Castanedo+L%22">Quintana-Castanedo L</searchLink>; Department of Dermatology, La Paz University Hospital, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22García+M%22">García M</searchLink>; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Suárez-Sancho+S%22">Suárez-Sancho S</searchLink>; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain.; ATMPs Production Unit-GMP Facility, Gregorio Marañón General University Hospital, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Yáñez+R%22">Yáñez R</searchLink>; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain.; Division of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas, Medioambientales, y Tecnológicas (CIEMAT)/Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER-ISCIII), Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz (IIS-FJD), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Pérez-Conde+I%22">Pérez-Conde I</searchLink>; Department of Dermatology, La Paz University Hospital, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Carretero+M%22">Carretero M</searchLink>; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez-Queipo+M%22">Martínez-Queipo M</searchLink>; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, United Kingdom.; National Institute for Health and Care Research (NIHR) Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22de+Paz+R%22">de Paz R</searchLink>; IdiPAZ, Hospital La Paz Insititute for Health Research, La Paz University Hospital, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22León+C%22">León C</searchLink>; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Jiménez-Yuste+V%22">Jiménez-Yuste V</searchLink>; Coagulopathies and Haemostasis Disorders Group, IdiPaz, Hematology and Haemotherapy Unit, La Paz University Hospital, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Borobia+AM%22">Borobia AM</searchLink>; Clinical Pharmacology Department, IdiPAZ, La Paz University Hospital, School of Medicine, Autonomous University of Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Vicente+Á%22">Vicente Á</searchLink>; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain.; Cell Biology Department, Faculty of Medicine, Complutense University, Madrid, Spain.; Stem Cells, Immunity and Cancer Group, Health Research Institute Hospital 12 de Octubre (i+ 12), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lwin+SM%22">Lwin SM</searchLink>; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, United Kingdom.; National Institute for Health and Care Research (NIHR) Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22McGrath+JA%22">McGrath JA</searchLink>; St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, United Kingdom.; National Institute for Health and Care Research (NIHR) Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fernández-Santos+ME%22">Fernández-Santos ME</searchLink>; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain.; ATMPs Production Unit-GMP Facility, Gregorio Marañón General University Hospital, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Butta+N%22">Butta N</searchLink>; Coagulopathies and Haemostasis Disorders Group, IdiPaz, Hematology and Haemotherapy Unit, La Paz University Hospital, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sacedón+R%22">Sacedón R</searchLink>; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain.; Cell Biology Department, Faculty of Medicine, Complutense University, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Del+Río+M%22">Del Río M</searchLink>; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22de+Lucas+R%22">de Lucas R</searchLink>; Department of Dermatology, La Paz University Hospital, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Escámez+MJ%22">Escámez MJ</searchLink>; U714-CIBERER (Centro de Investigación Biomédica en Red de Enfermedades Raras), Madrid, Madrid, Spain.; Department of Bioengineering, Universidad Carlos III de Madrid (UC3M), Madrid, Spain.; Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.; Spanish Network of Advanced Therapies by TERAV-ISCIII, Madrid, Spain.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 May 05; Vol. 17, pp. 1789537. <i>Date of Electronic Publication: </i>2026 May 05 (<i>Print Publication: </i>2026).
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