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A new paradigm: 46 structural cell types function as environment-supporting innate immune cells, with endothelial and vascular smooth muscle cells as key prototypes.

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Title: A new paradigm: 46 structural cell types function as environment-supporting innate immune cells, with endothelial and vascular smooth muscle cells as key prototypes.
Authors: Liu J; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA., Nanayakkara GK; Molecular Medicine Program, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT 84112, USA., Lu Y; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA., Saaoud F; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA., Xu K; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA., Shao Y; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA., Yuan B; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA., Hung SY; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA., Xiang H; Center for Metabolic Disease Research and Thrombosis Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA., Wang X; Center for Metabolic Disease Research and Thrombosis Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA., Mohsin S; Aging & Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA., Wu S; Center for Metabolic Disease Research and Thrombosis Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA., Liu X; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA., Wei J; Center for Metabolic Disease Research and Thrombosis Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA., Zhou Z; Center for Inflammation and Lung Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA., Kosmider B; Center for Inflammation and Lung Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA., Fu M; Department of Biomedical Science, School of Medicine, University of Missouri Kansas City, Kansas City, MO, 64108, USA., Martinez L; DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, 33136, USA., Vazquez-Padron R; DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, 33136, USA., Hu W; Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA., Ge S; Pediatric and Adult Congenital Cardiology, Geisinger Medical Center, Danville, PA, 17822, USA., Wang H; Center for Metabolic Disease Research and Thrombosis Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA., Yang X; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.; Center for Metabolic Disease Research and Thrombosis Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.
Source: INew medicine [Inew Med] 2026 May 18. Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article
Journal Info: Country of Publication: Australia NLM ID: 9919258816606676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 3067-2767 (Electronic) Linking ISSN: 30672767 NLM ISO Abbreviation: Inew Med
Database: MEDLINE Ultimate
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  Data: A new paradigm: 46 structural cell types function as environment-supporting innate immune cells, with endothelial and vascular smooth muscle cells as key prototypes.
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  Data: <searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.<br /><searchLink fieldCode="AU" term="%22Nanayakkara+GK%22">Nanayakkara GK</searchLink>; Molecular Medicine Program, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT 84112, USA.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.<br /><searchLink fieldCode="AU" term="%22Saaoud+F%22">Saaoud F</searchLink>; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.<br /><searchLink fieldCode="AU" term="%22Xu+K%22">Xu K</searchLink>; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.<br /><searchLink fieldCode="AU" term="%22Shao+Y%22">Shao Y</searchLink>; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+B%22">Yuan B</searchLink>; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.<br /><searchLink fieldCode="AU" term="%22Hung+SY%22">Hung SY</searchLink>; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.<br /><searchLink fieldCode="AU" term="%22Xiang+H%22">Xiang H</searchLink>; Center for Metabolic Disease Research and Thrombosis Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Center for Metabolic Disease Research and Thrombosis Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.<br /><searchLink fieldCode="AU" term="%22Mohsin+S%22">Mohsin S</searchLink>; Aging & Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.<br /><searchLink fieldCode="AU" term="%22Wu+S%22">Wu S</searchLink>; Center for Metabolic Disease Research and Thrombosis Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.<br /><searchLink fieldCode="AU" term="%22Wei+J%22">Wei J</searchLink>; Center for Metabolic Disease Research and Thrombosis Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+Z%22">Zhou Z</searchLink>; Center for Inflammation and Lung Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.<br /><searchLink fieldCode="AU" term="%22Kosmider+B%22">Kosmider B</searchLink>; Center for Inflammation and Lung Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.<br /><searchLink fieldCode="AU" term="%22Fu+M%22">Fu M</searchLink>; Department of Biomedical Science, School of Medicine, University of Missouri Kansas City, Kansas City, MO, 64108, USA.<br /><searchLink fieldCode="AU" term="%22Martinez+L%22">Martinez L</searchLink>; DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.<br /><searchLink fieldCode="AU" term="%22Vazquez-Padron+R%22">Vazquez-Padron R</searchLink>; DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.<br /><searchLink fieldCode="AU" term="%22Hu+W%22">Hu W</searchLink>; Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.<br /><searchLink fieldCode="AU" term="%22Ge+S%22">Ge S</searchLink>; Pediatric and Adult Congenital Cardiology, Geisinger Medical Center, Danville, PA, 17822, USA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Center for Metabolic Disease Research and Thrombosis Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.; Center for Metabolic Disease Research and Thrombosis Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.
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  Data: <i>Country of Publication: </i>Australia <i>NLM ID: </i>9919258816606676 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>3067-2767 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2230672767%22">30672767 </searchLink><i>NLM ISO Abbreviation: </i>Inew Med
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        Value: 10.1002/inm3.70050
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        Text: English
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              Text: 2026 May 18
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