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Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation.

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Title: Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation.
Authors: Fricke M; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany., Mechel A; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany., Evers L; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany., Twellsieck B; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany., Grein JM; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany., Cima-Omori MS; German Center for Neurodegenerative Diseases (DZNE), 37075 Goettingen, Germany., Al-Azzani M; University Medical Center Goettingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, 37073 Goettingen, Germany., Outeiro TF; German Center for Neurodegenerative Diseases (DZNE), 37075 Goettingen, Germany; University Medical Center Goettingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, 37073 Goettingen, Germany; Faculdade de Medicina e Ciências Biomédicas, Algarve Biomedical Center Research Institute (ABC-Ri), Universidade do Algarve, 8005-139 Faro, Portugal; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Zweckstetter M; German Center for Neurodegenerative Diseases (DZNE), 37075 Goettingen, Germany; Department for NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, 37077 Goettingen, Germany., Holzbaur ELF; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Boecker CA; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany. Electronic address: alexander.boecker@med.uni-goettingen.de.
Source: Cell reports [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117364. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation.
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  Data: <searchLink fieldCode="AU" term="%22Fricke+M%22">Fricke M</searchLink>; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany.<br /><searchLink fieldCode="AU" term="%22Mechel+A%22">Mechel A</searchLink>; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany.<br /><searchLink fieldCode="AU" term="%22Evers+L%22">Evers L</searchLink>; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany.<br /><searchLink fieldCode="AU" term="%22Twellsieck+B%22">Twellsieck B</searchLink>; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany.<br /><searchLink fieldCode="AU" term="%22Grein+JM%22">Grein JM</searchLink>; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany.<br /><searchLink fieldCode="AU" term="%22Cima-Omori+MS%22">Cima-Omori MS</searchLink>; German Center for Neurodegenerative Diseases (DZNE), 37075 Goettingen, Germany.<br /><searchLink fieldCode="AU" term="%22Al-Azzani+M%22">Al-Azzani M</searchLink>; University Medical Center Goettingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, 37073 Goettingen, Germany.<br /><searchLink fieldCode="AU" term="%22Outeiro+TF%22">Outeiro TF</searchLink>; German Center for Neurodegenerative Diseases (DZNE), 37075 Goettingen, Germany; University Medical Center Goettingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, 37073 Goettingen, Germany; Faculdade de Medicina e Ciências Biomédicas, Algarve Biomedical Center Research Institute (ABC-Ri), Universidade do Algarve, 8005-139 Faro, Portugal; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, NE2 4HH Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Zweckstetter+M%22">Zweckstetter M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), 37075 Goettingen, Germany; Department for NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, 37077 Goettingen, Germany.<br /><searchLink fieldCode="AU" term="%22Holzbaur+ELF%22">Holzbaur ELF</searchLink>; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Boecker+CA%22">Boecker CA</searchLink>; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany. Electronic address: alexander.boecker@med.uni-goettingen.de.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117364. <i>Date of Electronic Publication: </i>2026 May 21.
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              Text: 2026 Jun 23
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