Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation.
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| Title: | Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation. |
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| Authors: | Fricke M; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany., Mechel A; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany., Evers L; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany., Twellsieck B; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany., Grein JM; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany., Cima-Omori MS; German Center for Neurodegenerative Diseases (DZNE), 37075 Goettingen, Germany., Al-Azzani M; University Medical Center Goettingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, 37073 Goettingen, Germany., Outeiro TF; German Center for Neurodegenerative Diseases (DZNE), 37075 Goettingen, Germany; University Medical Center Goettingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, 37073 Goettingen, Germany; Faculdade de Medicina e Ciências Biomédicas, Algarve Biomedical Center Research Institute (ABC-Ri), Universidade do Algarve, 8005-139 Faro, Portugal; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Zweckstetter M; German Center for Neurodegenerative Diseases (DZNE), 37075 Goettingen, Germany; Department for NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, 37077 Goettingen, Germany., Holzbaur ELF; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Boecker CA; University Medical Center Goettingen, Department of Neurology, 37077 Goettingen, Germany. Electronic address: alexander.boecker@med.uni-goettingen.de. |
| Source: | Cell reports [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117364. Date of Electronic Publication: 2026 May 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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