Fulvestrant versus capecitabine as maintenance therapy in hormone receptor-positive, HER2-negative metastatic breast cancer after first-line chemotherapy (FAMILY): a multicenter, open-label, randomized, phase 3 trial.
Saved in:
| Title: | Fulvestrant versus capecitabine as maintenance therapy in hormone receptor-positive, HER2-negative metastatic breast cancer after first-line chemotherapy (FAMILY): a multicenter, open-label, randomized, phase 3 trial. |
|---|---|
| Authors: | Wu W; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China., Yang Y; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China., Chen H; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China., Lu Y; Department of Breast, Bone and Soft Tissue Oncology, Guangxi Medical University Cancer Hospital, Nanning, PR China., Zeng Y; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China., Zhao J; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China., Du C; Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, PR China., Lin Y; Breast Disease Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China., Peng P; Department of Breast Disease, The Fifth Affiliated Hospital of Sun-Yat-Sen University, Zhuhai, PR China., Huang M; Department of Breast Disease, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, PR China., Zhang Y; Cancer Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, PR China., Ouyang Q; Department of Breast Medicine, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, PR China., Ding L; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China., Cheng Z; Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, PR China., Wen Y; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China., Wu Z; Breast Disease Diagnosis and Treatment Center, Shantou Central Hospital, Shantou, PR China., Ye J; Department of Breast Disease, The First People's Hospital of Zhaoqing, Zhaoqing, PR China., Ling L; Clinical Research Design Division, Clinical Research Center, Sun Yat-sen Memorial Hospital, School of Public Health, Sun Yat-sen University, Guangzhou, PR China., Wang K; Department of Breast Cancer, Cancer Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, PR China., Lu Y; Department of Oncology, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, PR China., Zou G; Department of Oncology, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, PR China., Zhong J; Department of Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, PR China., Wang H; Department of Oncology, Nanchang People's Hospital, Nanchang, PR China., Lin D; Department of Oncology, Jiangmen Central Hospital, Jiangmen, PR China., Zeng; The Second Department of Internal Medicine, Cancer Hospital of Shantou University Medical College, Shantou, PR China., Yao C; Department of Breast Surgery, Sixth Affiliated Hospital of South China University of Technology, and Sixth Clinical College of South China University of Technology, Foshan, PR China., Chen Q; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, PR China.; Department of Breast, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, PR China., Zou L; Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, PR China., Wang S; Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China., Yu Y; Department of Medical Oncology, Phase I Clinical Trial Centre, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, PR China.; Guangdong Provincial Key Laboratory of Cancer Pathogenesis and Precision Diagnosis and Treatment, Joint Big Data Laboratory, Department of Medical Oncology, Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China., Yuan Z; Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China. yuanzhy@sysucc.org.cn., Wang Y; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China. yingwang1101@126.com., Yao H; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China. yaoherui@mail.sysu.edu.cn.; Department of Medical Oncology, Phase I Clinical Trial Centre, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, PR China. yaoherui@mail.sysu.edu.cn. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 May 22; Vol. 11 (1). Date of Electronic Publication: 2026 May 22. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42168151 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Fulvestrant versus capecitabine as maintenance therapy in hormone receptor-positive, HER2-negative metastatic breast cancer after first-line chemotherapy (FAMILY): a multicenter, open-label, randomized, phase 3 trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Wu+W%22">Wu W</searchLink>; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Department of Breast, Bone and Soft Tissue Oncology, Guangxi Medical University Cancer Hospital, Nanning, PR China.<br /><searchLink fieldCode="AU" term="%22Zeng+Y%22">Zeng Y</searchLink>; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Du+C%22">Du C</searchLink>; Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, PR China.<br /><searchLink fieldCode="AU" term="%22Lin+Y%22">Lin Y</searchLink>; Breast Disease Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Peng+P%22">Peng P</searchLink>; Department of Breast Disease, The Fifth Affiliated Hospital of Sun-Yat-Sen University, Zhuhai, PR China.<br /><searchLink fieldCode="AU" term="%22Huang+M%22">Huang M</searchLink>; Department of Breast Disease, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Cancer Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, PR China.<br /><searchLink fieldCode="AU" term="%22Ouyang+Q%22">Ouyang Q</searchLink>; Department of Breast Medicine, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, PR China.<br /><searchLink fieldCode="AU" term="%22Ding+L%22">Ding L</searchLink>; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Cheng+Z%22">Cheng Z</searchLink>; Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Wen+Y%22">Wen Y</searchLink>; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Breast Disease Diagnosis and Treatment Center, Shantou Central Hospital, Shantou, PR China.<br /><searchLink fieldCode="AU" term="%22Ye+J%22">Ye J</searchLink>; Department of Breast Disease, The First People's Hospital of Zhaoqing, Zhaoqing, PR China.<br /><searchLink fieldCode="AU" term="%22Ling+L%22">Ling L</searchLink>; Clinical Research Design Division, Clinical Research Center, Sun Yat-sen Memorial Hospital, School of Public Health, Sun Yat-sen University, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Wang+K%22">Wang K</searchLink>; Department of Breast Cancer, Cancer Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Department of Oncology, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Zou+G%22">Zou G</searchLink>; Department of Oncology, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Zhong+J%22">Zhong J</searchLink>; Department of Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, PR China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Oncology, Nanchang People's Hospital, Nanchang, PR China.<br /><searchLink fieldCode="AU" term="%22Lin+D%22">Lin D</searchLink>; Department of Oncology, Jiangmen Central Hospital, Jiangmen, PR China.<br /><searchLink fieldCode="AU" term="%22Zeng%22">Zeng</searchLink>; The Second Department of Internal Medicine, Cancer Hospital of Shantou University Medical College, Shantou, PR China.<br /><searchLink fieldCode="AU" term="%22Yao+C%22">Yao C</searchLink>; Department of Breast Surgery, Sixth Affiliated Hospital of South China University of Technology, and Sixth Clinical College of South China University of Technology, Foshan, PR China.<br /><searchLink fieldCode="AU" term="%22Chen+Q%22">Chen Q</searchLink>; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, PR China.; Department of Breast, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Zou+L%22">Zou L</searchLink>; Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, PR China.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Yu+Y%22">Yu Y</searchLink>; Department of Medical Oncology, Phase I Clinical Trial Centre, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, PR China.; Guangdong Provincial Key Laboratory of Cancer Pathogenesis and Precision Diagnosis and Treatment, Joint Big Data Laboratory, Department of Medical Oncology, Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Yuan+Z%22">Yuan Z</searchLink>; Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China. yuanzhy@sysucc.org.cn.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China. yingwang1101@126.com.<br /><searchLink fieldCode="AU" term="%22Yao+H%22">Yao H</searchLink>; Breast Tumor Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, PR China. yaoherui@mail.sysu.edu.cn.; Department of Medical Oncology, Phase I Clinical Trial Centre, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, PR China. yaoherui@mail.sysu.edu.cn. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101676423%22">Signal transduction and targeted therapy</searchLink> [Signal Transduct Target Ther] 2026 May 22; Vol. 11 (1). <i>Date of Electronic Publication: </i>2026 May 22. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101676423 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-3635 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220593635%22">20593635 </searchLink><i>NLM ISO Abbreviation: </i>Signal Transduct Target Ther <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42168151 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41392-026-02720-6 Languages: – Code: eng Text: English Titles: – TitleFull: Fulvestrant versus capecitabine as maintenance therapy in hormone receptor-positive, HER2-negative metastatic breast cancer after first-line chemotherapy (FAMILY): a multicenter, open-label, randomized, phase 3 trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wu W – PersonEntity: Name: NameFull: Yang Y – PersonEntity: Name: NameFull: Chen H – PersonEntity: Name: NameFull: Lu Y – PersonEntity: Name: NameFull: Zeng Y – PersonEntity: Name: NameFull: Zhao J – PersonEntity: Name: NameFull: Du C – PersonEntity: Name: NameFull: Lin Y – PersonEntity: Name: NameFull: Peng P – PersonEntity: Name: NameFull: Huang M – PersonEntity: Name: NameFull: Zhang Y – PersonEntity: Name: NameFull: Ouyang Q – PersonEntity: Name: NameFull: Ding L – PersonEntity: Name: NameFull: Cheng Z – PersonEntity: Name: NameFull: Wen Y – PersonEntity: Name: NameFull: Wu Z – PersonEntity: Name: NameFull: Ye J – PersonEntity: Name: NameFull: Ling L – PersonEntity: Name: NameFull: Wang K – PersonEntity: Name: NameFull: Lu Y – PersonEntity: Name: NameFull: Zou G – PersonEntity: Name: NameFull: Zhong J – PersonEntity: Name: NameFull: Wang H – PersonEntity: Name: NameFull: Lin D – PersonEntity: Name: NameFull: Zeng – PersonEntity: Name: NameFull: Yao C – PersonEntity: Name: NameFull: Chen Q – PersonEntity: Name: NameFull: Zou L – PersonEntity: Name: NameFull: Wang S – PersonEntity: Name: NameFull: Yu Y – PersonEntity: Name: NameFull: Yuan Z – PersonEntity: Name: NameFull: Wang Y – PersonEntity: Name: NameFull: Yao H IsPartOfRelationships: – BibEntity: Dates: – D: 22 M: 05 Text: 2026 May 22 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2059-3635 Numbering: – Type: volume Value: 11 – Type: issue Value: 1 Titles: – TitleFull: Signal transduction and targeted therapy Type: main |
| ResultId | 1 |
