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Structural basis and physiological significance of non-canonical Gs coupling to the melatonin MT1 receptor.

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Title: Structural basis and physiological significance of non-canonical Gs coupling to the melatonin MT1 receptor.
Authors: Oishi A; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France. aoishi@ks.kyorin-u.ac.jp.; Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, Japan. aoishi@ks.kyorin-u.ac.jp., Okamoto HH; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan., Ikegami K; Department of Physiology, School of Medicine, Aichi Medical University, Nagakute, Aichi, Japan.; Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University, Fukuoka, Japan., McHugh R; School of Pharmacy, Queen's University Belfast, Belfast, UK., Masri B; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France., Kusakizako T; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan., Kobayashi K; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan., Takaki A; Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University, Fukuoka, Japan., Karamitri A; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France., Cecon E; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France., Dam J; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France., Nagase M; Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, Japan., Tikhonova IG; School of Pharmacy, Queen's University Belfast, Belfast, UK., Nureki O; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. nureki@bs.s.u-tokyo.ac.jp., Jockers R; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France. ralf.jockers@inserm.fr.
Source: Nature communications [Nat Commun] 2026 May 21. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Oishi+A%22">Oishi A</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France. aoishi@ks.kyorin-u.ac.jp.; Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, Japan. aoishi@ks.kyorin-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Okamoto+HH%22">Okamoto HH</searchLink>; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ikegami+K%22">Ikegami K</searchLink>; Department of Physiology, School of Medicine, Aichi Medical University, Nagakute, Aichi, Japan.; Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22McHugh+R%22">McHugh R</searchLink>; School of Pharmacy, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Masri+B%22">Masri B</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France.<br /><searchLink fieldCode="AU" term="%22Kusakizako+T%22">Kusakizako T</searchLink>; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+K%22">Kobayashi K</searchLink>; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Takaki+A%22">Takaki A</searchLink>; Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Karamitri+A%22">Karamitri A</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France.<br /><searchLink fieldCode="AU" term="%22Cecon+E%22">Cecon E</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France.<br /><searchLink fieldCode="AU" term="%22Dam+J%22">Dam J</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France.<br /><searchLink fieldCode="AU" term="%22Nagase+M%22">Nagase M</searchLink>; Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tikhonova+IG%22">Tikhonova IG</searchLink>; School of Pharmacy, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Nureki+O%22">Nureki O</searchLink>; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. nureki@bs.s.u-tokyo.ac.jp.<br /><searchLink fieldCode="AU" term="%22Jockers+R%22">Jockers R</searchLink>; Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France. ralf.jockers@inserm.fr.
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