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Filamin-ETV4/5 acts as mechanosensor-mechanotransducer axis that drives cell competition-mediated elimination of transformed cells.

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Title: Filamin-ETV4/5 acts as mechanosensor-mechanotransducer axis that drives cell competition-mediated elimination of transformed cells.
Authors: Wen J; Department of Molecular Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Sai K; Department of Molecular Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. sai.kazuhito.4r@kyoto-u.ac.jp., Masutani S; Department of Molecular Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Aoshima Y; Department of Molecular Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Yumi K; Department of Molecular Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Kyo T; Department of Molecular Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Hasegawa J; Graduate School of Pharmaceutical Science, Kitasato University, Tokyo, Japan., Itoh T; Division of Membrane Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.; Biosignal Research Center, Kobe University, Kobe, Japan., Mizuta K; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Nakamura T; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; The Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan., Yabuta Y; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Saitou M; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan., Toda S; Institute for Protein Research, The University of Osaka, Suita, Japan., Fujita Y; Department of Molecular Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. fujita@monc.med.kyoto-u.ac.jp.
Source: Nature communications [Nat Commun] 2026 May 21. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Wen+J%22">Wen J</searchLink>; Department of Molecular Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Sai+K%22">Sai K</searchLink>; Department of Molecular Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. sai.kazuhito.4r@kyoto-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Masutani+S%22">Masutani S</searchLink>; Department of Molecular Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Aoshima+Y%22">Aoshima Y</searchLink>; Department of Molecular Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Yumi+K%22">Yumi K</searchLink>; Department of Molecular Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kyo+T%22">Kyo T</searchLink>; Department of Molecular Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Hasegawa+J%22">Hasegawa J</searchLink>; Graduate School of Pharmaceutical Science, Kitasato University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Itoh+T%22">Itoh T</searchLink>; Division of Membrane Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.; Biosignal Research Center, Kobe University, Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Mizuta+K%22">Mizuta K</searchLink>; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Nakamura+T%22">Nakamura T</searchLink>; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; The Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Yabuta+Y%22">Yabuta Y</searchLink>; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Saitou+M%22">Saitou M</searchLink>; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Toda+S%22">Toda S</searchLink>; Institute for Protein Research, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Fujita+Y%22">Fujita Y</searchLink>; Department of Molecular Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. fujita@monc.med.kyoto-u.ac.jp.
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