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Foamy microglia link oxylipins to disease progression in multiple sclerosis.

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Title: Foamy microglia link oxylipins to disease progression in multiple sclerosis.
Authors: van der Vliet D; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.; Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Di X; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands., Shamorkina TM; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, the Netherlands.; Netherlands Proteomics Center, Utrecht, the Netherlands., Coulon-Bainier C; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Pavlovic A; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., van der Vliet IACM; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands., Zeng Y; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands., Macnair W; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., van Egmond N; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands., Chen JQA; Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., van den Bosch AMR; Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Engelenburg HJ; Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Wever D; Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Mason MRJ; Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Driever WPF; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands., Gagestein B; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands., Dusseldorp E; Methodology and Statistics Unit, Institute of Psychology, Leiden University, Leiden, the Netherlands., van Eijk M; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands., Grether U; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Harms AC; Metabolomics and Analytics Centre, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands., Hankemeier T; Metabolomics and Analytics Centre, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands., Collin L; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland., Heck AJR; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, the Netherlands.; Netherlands Proteomics Center, Utrecht, the Netherlands., Huitinga I; Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands. i.huitinga@nin.knaw.nl.; Center for Neuroscience, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands. i.huitinga@nin.knaw.nl.; The Netherlands Brain Bank, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands. i.huitinga@nin.knaw.nl., van der Stelt M; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands. m.van.der.stelt@chem.leidenuniv.nl.
Corporate Authors: Netherlands Brain Bank
Source: Nature neuroscience [Nat Neurosci] 2026 May 21. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22van+der+Vliet+D%22">van der Vliet D</searchLink>; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.; Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Di+X%22">Di X</searchLink>; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Shamorkina+TM%22">Shamorkina TM</searchLink>; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, the Netherlands.; Netherlands Proteomics Center, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Coulon-Bainier+C%22">Coulon-Bainier C</searchLink>; Pharma Research and Early Development, Roche Innovation Center Basel, F. 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