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Advancing Precision Dosing of 5-FU: Population PK Model Development, Limited Sampling Strategies, and Fit-for-Use Application.

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Title: Advancing Precision Dosing of 5-FU: Population PK Model Development, Limited Sampling Strategies, and Fit-for-Use Application.
Authors: Tan Z; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands., Sancho-Araiz A; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Völler S; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Peeters SLJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.; Department of Clinical Pharmacy, Catharina Hospital Eindhoven, Eindhoven, The Netherlands., Manten T; Department of Clinical Pharmacy, Catharina Hospital Eindhoven, Eindhoven, The Netherlands., Deenen MJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.; Department of Clinical Pharmacy, Catharina Hospital Eindhoven, Eindhoven, The Netherlands., Maring JG; Department of Clinical Pharmacy, Isala Hospital Zwolle, Zwolle, The Netherlands., Bet PM; Department of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Centre, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Amsterdam, The Netherlands., Mathôt RAA; Department of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Centre, Amsterdam, The Netherlands., Knibbe CAJ; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.; Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, The Netherlands., Moes DJAR; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. d.j.a.r.moes@lumc.nl.
Source: Clinical pharmacokinetics [Clin Pharmacokinet] 2026 May 21. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Country of Publication: Switzerland NLM ID: 7606849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1926 (Electronic) Linking ISSN: 03125963 NLM ISO Abbreviation: Clin Pharmacokinet Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Tan+Z%22">Tan Z</searchLink>; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sancho-Araiz+A%22">Sancho-Araiz A</searchLink>; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Völler+S%22">Völler S</searchLink>; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Peeters+SLJ%22">Peeters SLJ</searchLink>; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.; Department of Clinical Pharmacy, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Manten+T%22">Manten T</searchLink>; Department of Clinical Pharmacy, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Deenen+MJ%22">Deenen MJ</searchLink>; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.; Department of Clinical Pharmacy, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Maring+JG%22">Maring JG</searchLink>; Department of Clinical Pharmacy, Isala Hospital Zwolle, Zwolle, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bet+PM%22">Bet PM</searchLink>; Department of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Centre, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mathôt+RAA%22">Mathôt RAA</searchLink>; Department of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Centre, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Knibbe+CAJ%22">Knibbe CAJ</searchLink>; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.; Department of Clinical Pharmacy, St Antonius Hospital, Nieuwegein, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Moes+DJAR%22">Moes DJAR</searchLink>; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. d.j.a.r.moes@lumc.nl.
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