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Mycobacterium tuberculosis-induced PCBP1 degradation drives macrophage ferroptosis to promote infection: a lung-macrophage-targeted RNAa nanotherapy.

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Title: Mycobacterium tuberculosis-induced PCBP1 degradation drives macrophage ferroptosis to promote infection: a lung-macrophage-targeted RNAa nanotherapy.
Authors: Huang HS; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.; Songshan Lake Innovation Center of Medicine & Engineering, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Chi JX; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.; Songshan Lake Innovation Center of Medicine & Engineering, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Wang JJ; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Xiao LY; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Chen L; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Lai SY; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Liu WY; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China., Yang F; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Liao KS; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Pi J; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.; Songshan Lake Innovation Center of Medicine & Engineering, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Cong YG; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China. ygcong@hotmail.com., Shao YM; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China. sym@gdmu.edu.cn., Xu JF; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China. xujunfa@gdmu.edu.cn.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China. xujunfa@gdmu.edu.cn.; Songshan Lake Innovation Center of Medicine & Engineering, Guangdong Medical University, Dongguan, 523808, Guangdong province, China. xujunfa@gdmu.edu.cn.
Source: Journal of nanobiotechnology [J Nanobiotechnology] 2026 May 21. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mycobacterium tuberculosis-induced PCBP1 degradation drives macrophage ferroptosis to promote infection: a lung-macrophage-targeted RNAa nanotherapy.
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  Data: <searchLink fieldCode="AU" term="%22Huang+HS%22">Huang HS</searchLink>; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.; Songshan Lake Innovation Center of Medicine & Engineering, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.<br /><searchLink fieldCode="AU" term="%22Chi+JX%22">Chi JX</searchLink>; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.; Songshan Lake Innovation Center of Medicine & Engineering, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.<br /><searchLink fieldCode="AU" term="%22Wang+JJ%22">Wang JJ</searchLink>; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.<br /><searchLink fieldCode="AU" term="%22Xiao+LY%22">Xiao LY</searchLink>; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.<br /><searchLink fieldCode="AU" term="%22Lai+SY%22">Lai SY</searchLink>; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.<br /><searchLink fieldCode="AU" term="%22Liu+WY%22">Liu WY</searchLink>; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.<br /><searchLink fieldCode="AU" term="%22Yang+F%22">Yang F</searchLink>; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.<br /><searchLink fieldCode="AU" term="%22Liao+KS%22">Liao KS</searchLink>; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.<br /><searchLink fieldCode="AU" term="%22Pi+J%22">Pi J</searchLink>; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.; Songshan Lake Innovation Center of Medicine & Engineering, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.<br /><searchLink fieldCode="AU" term="%22Cong+YG%22">Cong YG</searchLink>; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China. ygcong@hotmail.com.<br /><searchLink fieldCode="AU" term="%22Shao+YM%22">Shao YM</searchLink>; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China. sym@gdmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xu+JF%22">Xu JF</searchLink>; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China. xujunfa@gdmu.edu.cn.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China. xujunfa@gdmu.edu.cn.; Songshan Lake Innovation Center of Medicine & Engineering, Guangdong Medical University, Dongguan, 523808, Guangdong province, China. xujunfa@gdmu.edu.cn.
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1186/s12951-026-04569-x
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        Text: English
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      – TitleFull: Mycobacterium tuberculosis-induced PCBP1 degradation drives macrophage ferroptosis to promote infection: a lung-macrophage-targeted RNAa nanotherapy.
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              Text: 2026 May 21
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