Mycobacterium tuberculosis-induced PCBP1 degradation drives macrophage ferroptosis to promote infection: a lung-macrophage-targeted RNAa nanotherapy.
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| Title: | Mycobacterium tuberculosis-induced PCBP1 degradation drives macrophage ferroptosis to promote infection: a lung-macrophage-targeted RNAa nanotherapy. |
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| Authors: | Huang HS; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.; Songshan Lake Innovation Center of Medicine & Engineering, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Chi JX; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.; Songshan Lake Innovation Center of Medicine & Engineering, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Wang JJ; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Xiao LY; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Chen L; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Lai SY; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Liu WY; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China., Yang F; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Liao KS; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Pi J; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China.; Songshan Lake Innovation Center of Medicine & Engineering, Guangdong Medical University, Dongguan, 523808, Guangdong province, China., Cong YG; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China. ygcong@hotmail.com., Shao YM; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China. sym@gdmu.edu.cn., Xu JF; Dongguan Key Laboratory for Pathogenesis and Experimental Diagnosis of Infectious Diseases, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, 523710, Guangdong province, China. xujunfa@gdmu.edu.cn.; Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, 523808, Guangdong province, China. xujunfa@gdmu.edu.cn.; Songshan Lake Innovation Center of Medicine & Engineering, Guangdong Medical University, Dongguan, 523808, Guangdong province, China. xujunfa@gdmu.edu.cn. |
| Source: | Journal of nanobiotechnology [J Nanobiotechnology] 2026 May 21. Date of Electronic Publication: 2026 May 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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