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Age-related decline in nuclear envelope LINC complex drives neuronal aging via axon initial segment dysfunction.

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Title: Age-related decline in nuclear envelope LINC complex drives neuronal aging via axon initial segment dysfunction.
Authors: Hasegawa K; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan., Hama N; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan.; Department of Clinical Laboratory Science, Sanyo Women's College, Hiroshima, Japan., Amemiya M; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan., Zeng C; Faculty of Science and Engineering, Waseda University, Tokyo, Japan., Ito Y; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan., Suzuki S; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan., Nakamura K; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan., Kondo J; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan., Takeda C; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan., Kurihara Y; Department of Developmental Biology, School of Medicine, Shimane University, Izumo, Japan., Ikeda K; Department of Cell Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Fujita Y; Department of Developmental Biology, School of Medicine, Shimane University, Izumo, Japan., Okada Y; Department of Cell Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Laboratory for Cell Polarity Regulation, RIKEN Center for Biosystems Dynamics Research (BDR), Osaka, Japan.; Department of Physics, Graduate School of Science, The University of Tokyo, Tokyo, Japan.; Universal Biology Institute (UBI), The University of Tokyo, Tokyo, Japan.; International Research Center for Neurointelligence (WPI-IRCN), Institutes for Advanced Study, The University of Tokyo, Tokyo, Japan., Toyoda A; Comparative Genomics Laboratory, Department of Genomics and Evolutionary Biology, National Institute of Genetics, Mishima, Japan., Hamada M; Faculty of Science and Engineering, Waseda University, Tokyo, Japan.; AIST-Waseda University Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL), National Institute of Advanced Industrial Science and Technology, Tokyo, Japan., Kuwako KI; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan. kuwako@med.shimane-u.ac.jp.
Source: EMBO reports [EMBO Rep] 2026 May 22. Date of Electronic Publication: 2026 May 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Age-related decline in nuclear envelope LINC complex drives neuronal aging via axon initial segment dysfunction.
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  Data: <searchLink fieldCode="AU" term="%22Hasegawa+K%22">Hasegawa K</searchLink>; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan.<br /><searchLink fieldCode="AU" term="%22Hama+N%22">Hama N</searchLink>; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan.; Department of Clinical Laboratory Science, Sanyo Women's College, Hiroshima, Japan.<br /><searchLink fieldCode="AU" term="%22Amemiya+M%22">Amemiya M</searchLink>; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan.<br /><searchLink fieldCode="AU" term="%22Zeng+C%22">Zeng C</searchLink>; Faculty of Science and Engineering, Waseda University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ito+Y%22">Ito Y</searchLink>; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+S%22">Suzuki S</searchLink>; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan.<br /><searchLink fieldCode="AU" term="%22Nakamura+K%22">Nakamura K</searchLink>; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan.<br /><searchLink fieldCode="AU" term="%22Kondo+J%22">Kondo J</searchLink>; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan.<br /><searchLink fieldCode="AU" term="%22Takeda+C%22">Takeda C</searchLink>; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan.<br /><searchLink fieldCode="AU" term="%22Kurihara+Y%22">Kurihara Y</searchLink>; Department of Developmental Biology, School of Medicine, Shimane University, Izumo, Japan.<br /><searchLink fieldCode="AU" term="%22Ikeda+K%22">Ikeda K</searchLink>; Department of Cell Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Fujita+Y%22">Fujita Y</searchLink>; Department of Developmental Biology, School of Medicine, Shimane University, Izumo, Japan.<br /><searchLink fieldCode="AU" term="%22Okada+Y%22">Okada Y</searchLink>; Department of Cell Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Laboratory for Cell Polarity Regulation, RIKEN Center for Biosystems Dynamics Research (BDR), Osaka, Japan.; Department of Physics, Graduate School of Science, The University of Tokyo, Tokyo, Japan.; Universal Biology Institute (UBI), The University of Tokyo, Tokyo, Japan.; International Research Center for Neurointelligence (WPI-IRCN), Institutes for Advanced Study, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Toyoda+A%22">Toyoda A</searchLink>; Comparative Genomics Laboratory, Department of Genomics and Evolutionary Biology, National Institute of Genetics, Mishima, Japan.<br /><searchLink fieldCode="AU" term="%22Hamada+M%22">Hamada M</searchLink>; Faculty of Science and Engineering, Waseda University, Tokyo, Japan.; AIST-Waseda University Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL), National Institute of Advanced Industrial Science and Technology, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kuwako+KI%22">Kuwako KI</searchLink>; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan. kuwako@med.shimane-u.ac.jp.
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