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Development and validation of high-dose methotrexate population pharmacokinetic models to inform clinical decisions on dosing.

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Title: Development and validation of high-dose methotrexate population pharmacokinetic models to inform clinical decisions on dosing.
Authors: Blackman MH; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Yelvington B; Department of Oncology Pharmacy, Vanderbilt University Medical Center, Nashville, TN, USA., Beck C; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Cortez M; Department of Pharmacy, Rush MD Anderson Cancer Center, Chicago, IL, USA., Choi L; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. leena.choi@vumc.org.
Source: European journal of clinical pharmacology [Eur J Clin Pharmacol] 2026 May 23; Vol. 82 (6). Date of Electronic Publication: 2026 May 23.
Publication Type: Journal Article; Validation Study
Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 1256165 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1041 (Electronic) Linking ISSN: 00316970 NLM ISO Abbreviation: Eur J Clin Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Blackman+MH%22">Blackman MH</searchLink>; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Yelvington+B%22">Yelvington B</searchLink>; Department of Oncology Pharmacy, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Beck+C%22">Beck C</searchLink>; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Cortez+M%22">Cortez M</searchLink>; Department of Pharmacy, Rush MD Anderson Cancer Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Choi+L%22">Choi L</searchLink>; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. leena.choi@vumc.org.
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  Data: <searchLink fieldCode="JN" term="%221256165%22">European journal of clinical pharmacology</searchLink> [Eur J Clin Pharmacol] 2026 May 23; Vol. 82 (6). <i>Date of Electronic Publication: </i>2026 May 23.
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