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Exosomal ORF3a mediates lung-liver axis to dysregulate hepatic lipid metabolism in mild COVID-19.

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Title: Exosomal ORF3a mediates lung-liver axis to dysregulate hepatic lipid metabolism in mild COVID-19.
Authors: Qu Y; Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute, Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Zhou J; Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Wang X; Department of Infection Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA., Dong S; Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Li J; Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Qiu L; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Bian L; Department of Infection Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA., Yuan W; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Xie Q; Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. xieqingrjh@163.com., Qu J; Department of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. jmqu0906@163.com.; Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai, China. jmqu0906@163.com.; National Research Center for Translational Medicine at Shanghai, Shanghai, China. jmqu0906@163.com., Zhao Z; Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute, Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. zzhao5@tulane.edu.; Division of Biomedical Informatics & Genomics, John W. Deming Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA. zzhao5@tulane.edu., Wu X; Department of Infection Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA. wux4@ccf.org., Liang Q; Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. liangqiming@shsmu.edu.cn.; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China. liangqiming@shsmu.edu.cn.; Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai, China. liangqiming@shsmu.edu.cn.; Center for Immune-Related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. liangqiming@shsmu.edu.cn.
Source: Cell discovery [Cell Discov] 2026 May 23; Vol. 12 (1). Date of Electronic Publication: 2026 May 23.
Publication Type: Letter
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101661034 Publication Model: Electronic Cited Medium: Print ISSN: 2056-5968 (Print) Linking ISSN: 20565968 NLM ISO Abbreviation: Cell Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Exosomal ORF3a mediates lung-liver axis to dysregulate hepatic lipid metabolism in mild COVID-19.
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  Data: <searchLink fieldCode="AU" term="%22Qu+Y%22">Qu Y</searchLink>; Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute, Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Infection Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Dong+S%22">Dong S</searchLink>; Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Qiu+L%22">Qiu L</searchLink>; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bian+L%22">Bian L</searchLink>; Department of Infection Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+W%22">Yuan W</searchLink>; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xie+Q%22">Xie Q</searchLink>; Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. xieqingrjh@163.com.<br /><searchLink fieldCode="AU" term="%22Qu+J%22">Qu J</searchLink>; Department of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. jmqu0906@163.com.; Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai, China. jmqu0906@163.com.; National Research Center for Translational Medicine at Shanghai, Shanghai, China. jmqu0906@163.com.<br /><searchLink fieldCode="AU" term="%22Zhao+Z%22">Zhao Z</searchLink>; Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute, Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. zzhao5@tulane.edu.; Division of Biomedical Informatics & Genomics, John W. Deming Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA. zzhao5@tulane.edu.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Department of Infection Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA. wux4@ccf.org.<br /><searchLink fieldCode="AU" term="%22Liang+Q%22">Liang Q</searchLink>; Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. liangqiming@shsmu.edu.cn.; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China. liangqiming@shsmu.edu.cn.; Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai, China. liangqiming@shsmu.edu.cn.; Center for Immune-Related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. liangqiming@shsmu.edu.cn.
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