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Preserving the gut microbiome: hydrogel-forming microneedle delivery of tetracycline reduces gut microbiome disruption compared to oral administration.

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Title: Preserving the gut microbiome: hydrogel-forming microneedle delivery of tetracycline reduces gut microbiome disruption compared to oral administration.
Authors: Kelly SA; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK. stephen.kelly@qub.ac.uk.; School of Medicine and Centre for Interventions in Infection, Inflammation, and Immunity (4i), University of Limerick, Limerick, Ireland. stephen.kelly@qub.ac.uk., Zhao L; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK., Nzakizwanayo J; Department of Life Sciences, University of Bath, Claverton Down, Bath, BA2 7AX, UK., Rodgers AM; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK., Thompson TP; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK., Lee AJ; School of Biological Sciences, 19 Chlorine Gardens, Belfast, BT9 5DL, UK., McCarthy HO; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK., McGrath JW; School of Biological Sciences, 19 Chlorine Gardens, Belfast, BT9 5DL, UK., Ingram RJ; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK., Jones BV; Department of Life Sciences, University of Bath, Claverton Down, Bath, BA2 7AX, UK., Gilmore BF; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.; School of Medicine and Centre for Interventions in Infection, Inflammation, and Immunity (4i), University of Limerick, Limerick, Ireland., Donnelly RF; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Source: Drug delivery and translational research [Drug Deliv Transl Res] 2026 May 23. Date of Electronic Publication: 2026 May 23.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE
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  Data: Preserving the gut microbiome: hydrogel-forming microneedle delivery of tetracycline reduces gut microbiome disruption compared to oral administration.
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  Data: <searchLink fieldCode="AU" term="%22Kelly+SA%22">Kelly SA</searchLink>; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK. stephen.kelly@qub.ac.uk.; School of Medicine and Centre for Interventions in Infection, Inflammation, and Immunity (4i), University of Limerick, Limerick, Ireland. stephen.kelly@qub.ac.uk.<br /><searchLink fieldCode="AU" term="%22Zhao+L%22">Zhao L</searchLink>; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.<br /><searchLink fieldCode="AU" term="%22Nzakizwanayo+J%22">Nzakizwanayo J</searchLink>; Department of Life Sciences, University of Bath, Claverton Down, Bath, BA2 7AX, UK.<br /><searchLink fieldCode="AU" term="%22Rodgers+AM%22">Rodgers AM</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.<br /><searchLink fieldCode="AU" term="%22Thompson+TP%22">Thompson TP</searchLink>; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.<br /><searchLink fieldCode="AU" term="%22Lee+AJ%22">Lee AJ</searchLink>; School of Biological Sciences, 19 Chlorine Gardens, Belfast, BT9 5DL, UK.<br /><searchLink fieldCode="AU" term="%22McCarthy+HO%22">McCarthy HO</searchLink>; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.<br /><searchLink fieldCode="AU" term="%22McGrath+JW%22">McGrath JW</searchLink>; School of Biological Sciences, 19 Chlorine Gardens, Belfast, BT9 5DL, UK.<br /><searchLink fieldCode="AU" term="%22Ingram+RJ%22">Ingram RJ</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.<br /><searchLink fieldCode="AU" term="%22Jones+BV%22">Jones BV</searchLink>; Department of Life Sciences, University of Bath, Claverton Down, Bath, BA2 7AX, UK.<br /><searchLink fieldCode="AU" term="%22Gilmore+BF%22">Gilmore BF</searchLink>; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.; School of Medicine and Centre for Interventions in Infection, Inflammation, and Immunity (4i), University of Limerick, Limerick, Ireland.<br /><searchLink fieldCode="AU" term="%22Donnelly+RF%22">Donnelly RF</searchLink>; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
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  Data: <searchLink fieldCode="JN" term="%22101540061%22">Drug delivery and translational research</searchLink> [Drug Deliv Transl Res] 2026 May 23. <i>Date of Electronic Publication: </i>2026 May 23.
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        Value: 10.1007/s13346-026-02154-1
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              Text: 2026 May 23
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