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Small-molecule modulators of HIPK4 activity and proteostasis.

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Title: Small-molecule modulators of HIPK4 activity and proteostasis.
Authors: Zhuang Z; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA., Togashi RK; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.; Department of Chemistry, Stanford University, Stanford, CA, USA., Kearney P; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Pass I; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Swick SM; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.; Current address: Cooley LLP, Palo Alto, CA, USA., Zeng FY; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Bobkov AA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Fujimoto LM; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Dutta S; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Zerva A; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Frankfurt am Main, Germany., Raig ND; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Frankfurt am Main, Germany., Saha D; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Emami A; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Schwalm MP; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Frankfurt am Main, Germany., Moon BK; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA., Howard ST; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA., Knapp S; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Frankfurt am Main, Germany., Hanke T; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Frankfurt am Main, Germany., Chung TDY; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Chen JK; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.; Department of Chemistry, Stanford University, Stanford, CA, USA.; Department of Developmental Biology, Stanford University, Stanford, CA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 14. Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Zhuang+Z%22">Zhuang Z</searchLink>; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Togashi+RK%22">Togashi RK</searchLink>; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.; Department of Chemistry, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kearney+P%22">Kearney P</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pass+I%22">Pass I</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Swick+SM%22">Swick SM</searchLink>; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.; Current address: Cooley LLP, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zeng+FY%22">Zeng FY</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bobkov+AA%22">Bobkov AA</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fujimoto+LM%22">Fujimoto LM</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dutta+S%22">Dutta S</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zerva+A%22">Zerva A</searchLink>; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Raig+ND%22">Raig ND</searchLink>; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Saha+D%22">Saha D</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Emami+A%22">Emami A</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schwalm+MP%22">Schwalm MP</searchLink>; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Moon+BK%22">Moon BK</searchLink>; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Howard+ST%22">Howard ST</searchLink>; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Knapp+S%22">Knapp S</searchLink>; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Hanke+T%22">Hanke T</searchLink>; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Chung+TDY%22">Chung TDY</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+JK%22">Chen JK</searchLink>; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.; Department of Chemistry, Stanford University, Stanford, CA, USA.; Department of Developmental Biology, Stanford University, Stanford, CA, USA.
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