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GSDME acts as an epigenetic modifier to promote melanoma development via centriole biogenesis regulator PLK4.

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Title: GSDME acts as an epigenetic modifier to promote melanoma development via centriole biogenesis regulator PLK4.
Authors: Du J; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Yang Y; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Zhao M; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Zhang H; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Li X; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Qu D; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Wang J; Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Wang X; Department of Clinical Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Yi X; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Ma J; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Wang H; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Wang H; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Shi Q; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Tian Y; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Zhang B; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Guo S; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Gao T; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Guo W; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. guown@fmmu.edu.cn.; Innovation Research Institute, Xijing Hospital, Fourth Military Medical University, Xi'an, China. guown@fmmu.edu.cn.; Military Medical Innovation Center, Fourth Military Medical University, Xi'an, China. guown@fmmu.edu.cn., Li C; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. lichying@fmmu.edu.cn.
Source: Cell death and differentiation [Cell Death Differ] 2026 May 25. Date of Electronic Publication: 2026 May 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: GSDME acts as an epigenetic modifier to promote melanoma development via centriole biogenesis regulator PLK4.
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  Data: <searchLink fieldCode="AU" term="%22Du+J%22">Du J</searchLink>; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Zhao+M%22">Zhao M</searchLink>; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Qu+D%22">Qu D</searchLink>; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Clinical Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Yi+X%22">Yi X</searchLink>; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Shi+Q%22">Shi Q</searchLink>; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Tian+Y%22">Tian Y</searchLink>; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Guo+S%22">Guo S</searchLink>; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Gao+T%22">Gao T</searchLink>; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Guo+W%22">Guo W</searchLink>; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. guown@fmmu.edu.cn.; Innovation Research Institute, Xijing Hospital, Fourth Military Medical University, Xi'an, China. guown@fmmu.edu.cn.; Military Medical Innovation Center, Fourth Military Medical University, Xi'an, China. guown@fmmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. lichying@fmmu.edu.cn.
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