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Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells.

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Title: Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells.
Authors: Sabol AL; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139., Mengiste AA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139., Singh P; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142., Sreekanth V; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142., Hendel SJ; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139., Tran MTN; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139., Barybin AM; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139., Chaudhary S; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142., Harris RM; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139., Liivak KE; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139., Severance ZC; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142., Locicero CM; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139., Kailass K; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142., Lee C; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142., Xu LQ; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142., Butty VL; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.; BioMicro Center, Massachusetts Institute of Technology, Cambridge, MA 02139., Choudhary A; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.; Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA 02115.; Division of Engineering in Medicine, Brigham and Women's Hospital, Boston, MA 02115.; Department of Medicine, Harvard Medical School, Boston, MA 02115., Shoulders MD; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 02; Vol. 123 (22), pp. e2536003123. Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE; In Process
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