Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo.
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| Title: | Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo. |
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| Authors: | Han X; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; State Key Laboratory of RNA Innovation, Science and Engineering, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China., Xu Y; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; School of Pharmacy, East China Normal University, Shanghai 200062, China., Ricciardi AS; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; Division of Pediatric General, Thoracic, and Fetal Surgery, The Center for Fetal Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104., Xu J; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Xiang Y; Department of Biomedical Engineering, Duke University, Durham, NC 27705., Palanki R; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; Division of Pediatric General, Thoracic, and Fetal Surgery, The Center for Fetal Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104., Chowdhary V; Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Xue L; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Gong N; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104., Alameh MG; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Peranteau WH; Division of Pediatric General, Thoracic, and Fetal Surgery, The Center for Fetal Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104., Wilson JM; Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Reker D; Department of Biomedical Engineering, Duke University, Durham, NC 27705., Weissman D; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Mitchell MJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Center for Precision Engineering for Health, University of Pennsylvania, Philadelphia, PA 19104. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 02; Vol. 123 (22), pp. e2528144123. Date of Electronic Publication: 2026 May 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42190011 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Han+X%22">Han X</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; State Key Laboratory of RNA Innovation, Science and Engineering, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; School of Pharmacy, East China Normal University, Shanghai 200062, China.<br /><searchLink fieldCode="AU" term="%22Ricciardi+AS%22">Ricciardi AS</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; Division of Pediatric General, Thoracic, and Fetal Surgery, The Center for Fetal Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Xiang+Y%22">Xiang Y</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC 27705.<br /><searchLink fieldCode="AU" term="%22Palanki+R%22">Palanki R</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; Division of Pediatric General, Thoracic, and Fetal Surgery, The Center for Fetal Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Chowdhary+V%22">Chowdhary V</searchLink>; Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Xue+L%22">Xue L</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Gong+N%22">Gong N</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Alameh+MG%22">Alameh MG</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Peranteau+WH%22">Peranteau WH</searchLink>; Division of Pediatric General, Thoracic, and Fetal Surgery, The Center for Fetal Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Wilson+JM%22">Wilson JM</searchLink>; Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Reker+D%22">Reker D</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC 27705.<br /><searchLink fieldCode="AU" term="%22Weissman+D%22">Weissman D</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Mitchell+MJ%22">Mitchell MJ</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.; Center for Precision Engineering for Health, University of Pennsylvania, Philadelphia, PA 19104. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Jun 02; Vol. 123 (22), pp. e2528144123. <i>Date of Electronic Publication: </i>2026 May 26. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22National+Academy+of+Sciences%22">National Academy of Sciences </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7505876 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1091-6490 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200278424%22">00278424 </searchLink><i>NLM ISO Abbreviation: </i>Proc Natl Acad Sci U S A <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42190011 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1073/pnas.2528144123 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e2528144123 Titles: – TitleFull: Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Han X – PersonEntity: Name: NameFull: Xu Y – PersonEntity: Name: NameFull: Ricciardi AS – PersonEntity: Name: NameFull: Xu J – PersonEntity: Name: NameFull: Xiang Y – PersonEntity: Name: NameFull: Palanki R – PersonEntity: Name: NameFull: Chowdhary V – PersonEntity: Name: NameFull: Xue L – PersonEntity: Name: NameFull: Gong N – PersonEntity: Name: NameFull: Alameh MG – PersonEntity: Name: NameFull: Peranteau WH – PersonEntity: Name: NameFull: Wilson JM – PersonEntity: Name: NameFull: Reker D – PersonEntity: Name: NameFull: Weissman D – PersonEntity: Name: NameFull: Mitchell MJ IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 06 Text: 2026 Jun 02 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1091-6490 Numbering: – Type: volume Value: 123 – Type: issue Value: 22 Titles: – TitleFull: Proceedings of the National Academy of Sciences of the United States of America Type: main |
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