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Coexistence of TP53 and KRAS mutations identifies a molecular subset of biliary tract cancer with poor overall survival after first-line immunochemotherapy.

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Title: Coexistence of TP53 and KRAS mutations identifies a molecular subset of biliary tract cancer with poor overall survival after first-line immunochemotherapy.
Authors: Ishikawa S; Department of Clinical Oncology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan., Ouchi K; Department of Clinical Oncology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan., Wakayama S; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan., Oyamada S; Clinical Research Data Center, Tohoku University Hospital, Sendai, Miyagi, Japan., Iwasaki T; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan., Numakura R; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan., Yoshida Y; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan., Taniguchi S; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan., Kasahara Y; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan., Komine K; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan., Saijo K; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan., Shirota H; Department of Clinical Oncology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan., Kawakami H; Department of Clinical Oncology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan. Electronic address: kawakami_h@tohoku.ac.jp.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2026 Jun 25; Vol. 242, pp. 116826. Date of Electronic Publication: 2026 May 23.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Coexistence of TP53 and KRAS mutations identifies a molecular subset of biliary tract cancer with poor overall survival after first-line immunochemotherapy.
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  Data: <searchLink fieldCode="AU" term="%22Ishikawa+S%22">Ishikawa S</searchLink>; Department of Clinical Oncology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan.<br /><searchLink fieldCode="AU" term="%22Ouchi+K%22">Ouchi K</searchLink>; Department of Clinical Oncology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan.<br /><searchLink fieldCode="AU" term="%22Wakayama+S%22">Wakayama S</searchLink>; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan.<br /><searchLink fieldCode="AU" term="%22Oyamada+S%22">Oyamada S</searchLink>; Clinical Research Data Center, Tohoku University Hospital, Sendai, Miyagi, Japan.<br /><searchLink fieldCode="AU" term="%22Iwasaki+T%22">Iwasaki T</searchLink>; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan.<br /><searchLink fieldCode="AU" term="%22Numakura+R%22">Numakura R</searchLink>; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshida+Y%22">Yoshida Y</searchLink>; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan.<br /><searchLink fieldCode="AU" term="%22Taniguchi+S%22">Taniguchi S</searchLink>; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan.<br /><searchLink fieldCode="AU" term="%22Kasahara+Y%22">Kasahara Y</searchLink>; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan.<br /><searchLink fieldCode="AU" term="%22Komine+K%22">Komine K</searchLink>; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan.<br /><searchLink fieldCode="AU" term="%22Saijo+K%22">Saijo K</searchLink>; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan.<br /><searchLink fieldCode="AU" term="%22Shirota+H%22">Shirota H</searchLink>; Department of Clinical Oncology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan.<br /><searchLink fieldCode="AU" term="%22Kawakami+H%22">Kawakami H</searchLink>; Department of Clinical Oncology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan; Department of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan. Electronic address: kawakami_h@tohoku.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%229005373%22">European journal of cancer (Oxford, England : 1990)</searchLink> [Eur J Cancer] 2026 Jun 25; Vol. 242, pp. 116826. <i>Date of Electronic Publication: </i>2026 May 23.
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