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Fatty acid channelling into triglycerides and oxylipins drives ferroptosis resistance during oncogenic BRAF-induced senescence.

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Title: Fatty acid channelling into triglycerides and oxylipins drives ferroptosis resistance during oncogenic BRAF-induced senescence.
Authors: Hess MS; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Al-Shami KM; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Caballero CD; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Haenlin J; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Chaves-Filho AB; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil., Schlicker L; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg., Poeller P; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Vogel FCE; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Koltsaki I; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Gedik D; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Alonso MC; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Walz S; Comprehensive Cancer Center Mainfranken, Würzburg, Germany., Ade CP; Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Am Hubland, Würzburg, Germany., Eilers M; Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Am Hubland, Würzburg, Germany., Straub BK; Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Utikal JS; Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.; DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Heidelberg, Germany., Meierjohann S; Institute of Pathology, Julius Maximilians University and Comprehensive Cancer Center (CCC) Mainfranken, Würzburg, Germany., Rosenfeldt MT; Institute of Pathology, Julius Maximilians University and Comprehensive Cancer Center (CCC) Mainfranken, Würzburg, Germany., Snaebjornsson MT; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Schulze A; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany. Almut.schulze@dkfz-heidelberg.de.
Source: Cell death and differentiation [Cell Death Differ] 2026 May 26. Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Fatty acid channelling into triglycerides and oxylipins drives ferroptosis resistance during oncogenic BRAF-induced senescence.
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  Data: <searchLink fieldCode="AU" term="%22Hess+MS%22">Hess MS</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Al-Shami+KM%22">Al-Shami KM</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Caballero+CD%22">Caballero CD</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Haenlin+J%22">Haenlin J</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Chaves-Filho+AB%22">Chaves-Filho AB</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Schlicker+L%22">Schlicker L</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Poeller+P%22">Poeller P</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Vogel+FCE%22">Vogel FCE</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Koltsaki+I%22">Koltsaki I</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gedik+D%22">Gedik D</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Alonso+MC%22">Alonso MC</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Walz+S%22">Walz S</searchLink>; Comprehensive Cancer Center Mainfranken, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ade+CP%22">Ade CP</searchLink>; Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Am Hubland, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Eilers+M%22">Eilers M</searchLink>; Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Am Hubland, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Straub+BK%22">Straub BK</searchLink>; Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Utikal+JS%22">Utikal JS</searchLink>; Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.; DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Meierjohann+S%22">Meierjohann S</searchLink>; Institute of Pathology, Julius Maximilians University and Comprehensive Cancer Center (CCC) Mainfranken, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rosenfeldt+MT%22">Rosenfeldt MT</searchLink>; Institute of Pathology, Julius Maximilians University and Comprehensive Cancer Center (CCC) Mainfranken, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Snaebjornsson+MT%22">Snaebjornsson MT</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schulze+A%22">Schulze A</searchLink>; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany. Almut.schulze@dkfz-heidelberg.de.
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