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A framework for building a synthetic cell from the SynCell Asia Initiative.

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Title: A framework for building a synthetic cell from the SynCell Asia Initiative.
Authors: Dai Z; State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Aoki W; Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan., Chaiyen P; School of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Rayong, Thailand., Chang MW; NUS Synthetic Biology for Clinical and Technological Innovation, Yong Loo Lin School of Medicine, National University of Singapore, and National Centre for Engineering Biology, Singapore, Singapore., Chen X; Singapore Institute of Food and Biotechnology Innovation, Agency for Science, Technology and Research, Singapore, Singapore., Chen Z; School of Life Sciences, Westlake University, Hangzhou, China., Cho BK; Graduate School of Engineering Biology, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea., Deng NN; State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China., Du S; State Key Laboratory of Metabolism and Regulation in Complex Organisms, College of Life Sciences, Wuhan University, Wuhan, China., Foo JL; NUS Synthetic Biology for Clinical and Technological Innovation, Yong Loo Lin School of Medicine, National University of Singapore, and National Centre for Engineering Biology, Singapore, Singapore., Fredens J; NUS Synthetic Biology for Clinical and Technological Innovation, Yong Loo Lin School of Medicine, National University of Singapore, and National Centre for Engineering Biology, Singapore, Singapore., Fu M; State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Han X; State Key Laboratory of Urban-Rural Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, China., Hasunuma T; Engineering Biology Research Center, Kobe University, Kobe, Japan., Ichihashi N; Department of Life Science, Graduate School of Arts and Science, University of Tokyo, Tokyo, Japan., Isa NM; Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Malaysia., Kiga D; Department of Electrical Engineering and Bioscience, Waseda University, Tokyo, Japan., Kim DM; Department of Chemical Engineering and Applied Chemistry, Chungnam National University, Daejeon, Republic of Korea., Kim J; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea., Kondo A; Engineering Biology Research Center, Kobe University, Kobe, Japan., Kosaka Y; Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan., Laoteng K; National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Pathum Thani, Thailand., Lee J; Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea., Li J; School of Physical Science and Technology, ShanghaiTech University, Shanghai, China., Li J; Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China., Li M; Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China., Lim S; School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore., Liu J; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, China., Liu X; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Lu Y; State Key Laboratory of Green Biomanufacturing, Key Laboratory of Industrial Biocatalysis (Ministry of Education), Department of Chemical Engineering, Tsinghua University, Beijing, China., Luo N; State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Matsuura T; Earth-Life Science Institute, Institute of Science Tokyo, Tokyo, Japan., Mizunashi W; New Energy and Industrial Technology Development Organization, Kanagawa, Japan., Qiao Y; Beijing National Laboratory for Molecular Sciences (BNLMS), Laboratory of Polymer Physics and Chemistry, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China., Ramzi AB; Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia (UKM), Bangi, Malaysia., Seo SW; School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea., Shimizu Y; RIKEN Center for Biosystems Dynamics Research, Kobe, Japan., Shin K; Department of Chemistry and Institute of Biological Interfaces, Sogang University, Seoul, Republic of Korea., Tian L; Zhejiang Key Laboratory of Intelligent Sensing Technology and Advanced Medical Instrument, Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China., Vongsangnak W; Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, Thailand., Wang B; College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China., Zhang CC; Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China., Zhang XE; Faculty of Synthetic Biology, Shenzhen University of Advanced Technology, Shenzhen, China., Zhao G; Microbiome-X, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China., Zheng B; Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China., Zhou Y; Institute of Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, China., Liu C; State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. cl.liu@siat.ac.cn.
Source: Nature biotechnology [Nat Biotechnol] 2026 May 26. Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE
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  Data: A framework for building a synthetic cell from the SynCell Asia Initiative.
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  Data: <searchLink fieldCode="AU" term="%22Dai+Z%22">Dai Z</searchLink>; State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Aoki+W%22">Aoki W</searchLink>; Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Chaiyen+P%22">Chaiyen P</searchLink>; School of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Rayong, Thailand.<br /><searchLink fieldCode="AU" term="%22Chang+MW%22">Chang MW</searchLink>; NUS Synthetic Biology for Clinical and Technological Innovation, Yong Loo Lin School of Medicine, National University of Singapore, and National Centre for Engineering Biology, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Singapore Institute of Food and Biotechnology Innovation, Agency for Science, Technology and Research, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; School of Life Sciences, Westlake University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Cho+BK%22">Cho BK</searchLink>; Graduate School of Engineering Biology, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Deng+NN%22">Deng NN</searchLink>; State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Du+S%22">Du S</searchLink>; State Key Laboratory of Metabolism and Regulation in Complex Organisms, College of Life Sciences, Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Foo+JL%22">Foo JL</searchLink>; NUS Synthetic Biology for Clinical and Technological Innovation, Yong Loo Lin School of Medicine, National University of Singapore, and National Centre for Engineering Biology, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Fredens+J%22">Fredens J</searchLink>; 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National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Pathum Thani, Thailand.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; School of Physical Science and Technology, ShanghaiTech University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lim+S%22">Lim S</searchLink>; 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Earth-Life Science Institute, Institute of Science Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Mizunashi+W%22">Mizunashi W</searchLink>; New Energy and Industrial Technology Development Organization, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Qiao+Y%22">Qiao Y</searchLink>; Beijing National Laboratory for Molecular Sciences (BNLMS), Laboratory of Polymer Physics and Chemistry, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Ramzi+AB%22">Ramzi AB</searchLink>; Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia (UKM), Bangi, Malaysia.<br /><searchLink fieldCode="AU" term="%22Seo+SW%22">Seo SW</searchLink>; School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Shimizu+Y%22">Shimizu Y</searchLink>; RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Shin+K%22">Shin K</searchLink>; 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