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The Gut-Muscle Axis in Sarcopenia: Mechanisms, Evidence Gaps and Translational Challenges.

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Title: The Gut-Muscle Axis in Sarcopenia: Mechanisms, Evidence Gaps and Translational Challenges.
Authors: Marchitto SA; Gastroenterology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy., Abbatecola G; Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy., Zeidan RS; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32611, USA.; Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL 32611, USA., Morgan L; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32611, USA., Calvani R; Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.; Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, 00168 Rome, Italy., Picca A; Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, 00168 Rome, Italy.; Department of Medicine and Surgery, LUM University, 70010 Casamassima, Italy., Schlögl M; Division of Geriatric Medicine, Clinic Barmelweid, 5017 Erlinsbach, Switzerland., Tosato M; Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.; Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, 00168 Rome, Italy., Leeuwenburgh C; Department of Medicine, Division of Geriatric Medicine, College of Medicine, University of Florida, Gainesville, FL 32611, USA., Anton SD; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32611, USA., Landi F; Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.; Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, 00168 Rome, Italy., Marzetti E; Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.; Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, 00168 Rome, Italy., Cacciatore S; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32611, USA.
Source: Biomedicines [Biomedicines] 2026 Apr 23; Vol. 14 (5). Date of Electronic Publication: 2026 Apr 23.
Publication Type: Journal Article; Review
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: The Gut-Muscle Axis in Sarcopenia: Mechanisms, Evidence Gaps and Translational Challenges.
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  Data: <searchLink fieldCode="AU" term="%22Marchitto+SA%22">Marchitto SA</searchLink>; Gastroenterology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Abbatecola+G%22">Abbatecola G</searchLink>; Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Zeidan+RS%22">Zeidan RS</searchLink>; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32611, USA.; Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL 32611, USA.<br /><searchLink fieldCode="AU" term="%22Morgan+L%22">Morgan L</searchLink>; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32611, USA.<br /><searchLink fieldCode="AU" term="%22Calvani+R%22">Calvani R</searchLink>; Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.; Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, 00168 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Picca+A%22">Picca A</searchLink>; Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, 00168 Rome, Italy.; Department of Medicine and Surgery, LUM University, 70010 Casamassima, Italy.<br /><searchLink fieldCode="AU" term="%22Schlögl+M%22">Schlögl M</searchLink>; Division of Geriatric Medicine, Clinic Barmelweid, 5017 Erlinsbach, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tosato+M%22">Tosato M</searchLink>; Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.; Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, 00168 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Leeuwenburgh+C%22">Leeuwenburgh C</searchLink>; Department of Medicine, Division of Geriatric Medicine, College of Medicine, University of Florida, Gainesville, FL 32611, USA.<br /><searchLink fieldCode="AU" term="%22Anton+SD%22">Anton SD</searchLink>; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32611, USA.<br /><searchLink fieldCode="AU" term="%22Landi+F%22">Landi F</searchLink>; Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.; Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, 00168 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Marzetti+E%22">Marzetti E</searchLink>; Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.; Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, 00168 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Cacciatore+S%22">Cacciatore S</searchLink>; Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32611, USA.
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  Data: <searchLink fieldCode="JN" term="%22101691304%22">Biomedicines</searchLink> [Biomedicines] 2026 Apr 23; Vol. 14 (5). <i>Date of Electronic Publication: </i>2026 Apr 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22MDPI+AG%22">MDPI AG </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101691304 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2227-9059 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222279059%22">22279059 </searchLink><i>NLM ISO Abbreviation: </i>Biomedicines <i>Subsets: </i>PubMed not MEDLINE
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