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NF-κB inducing kinase (NIK) deletion accelerates KRAS-driven pancreatic cancer in association with tumor microenvironment remodeling.

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Title: NF-κB inducing kinase (NIK) deletion accelerates KRAS-driven pancreatic cancer in association with tumor microenvironment remodeling.
Authors: Du Z; Institute of Physiological Chemistry, University of Ulm, Ulm, Baden-Württemberg, Germany., Büttner UFG; Institute of Physiological Chemistry, University of Ulm, Ulm, Baden-Württemberg, Germany., Wirth HL; Institute of Physiological Chemistry, University of Ulm, Ulm, Baden-Württemberg, Germany., Gerstenlauer M; Institute of Physiological Chemistry, University of Ulm, Ulm, Baden-Württemberg, Germany., Manfras U; Institute of Physiological Chemistry, University of Ulm, Ulm, Baden-Württemberg, Germany., Loidl R; Institute of Physiological Chemistry, University of Ulm, Ulm, Baden-Württemberg, Germany., Bahçeci D; Institute of Physiological Chemistry, University of Ulm, Ulm, Baden-Württemberg, Germany., Steiger K; Institute of Pathology, Technical University Munich, Munich, Bayern, Germany.; Comparative Experimental Pathology (CEP), School of Medicine and Health, Technical University Munich, Munich, Bayern, Germany., Metzler T; Institute of Pathology, Technical University Munich, Munich, Bayern, Germany.; Comparative Experimental Pathology (CEP), School of Medicine and Health, Technical University Munich, Munich, Bayern, Germany., Chan LK; Department of Pathology and Molecular Pathology, University Hospital of Zurich, Zurich, Switzerland., Tsesmelis M; Single-Cell Sequencing Unit, University of Ulm, Ulm, Baden-Württemberg, Germany. miltiadis.tsesmelis@uni-ulm.de., Wirth T; Institute of Physiological Chemistry, University of Ulm, Ulm, Baden-Württemberg, Germany. thomas.wirth@uni-ulm.de.
Source: Cell death & disease [Cell Death Dis] 2026 May 27; Vol. 17 (1). Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: NF-κB inducing kinase (NIK) deletion accelerates KRAS-driven pancreatic cancer in association with tumor microenvironment remodeling.
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  Data: <searchLink fieldCode="AU" term="%22Du+Z%22">Du Z</searchLink>; Institute of Physiological Chemistry, University of Ulm, Ulm, Baden-Württemberg, Germany.<br /><searchLink fieldCode="AU" term="%22Büttner+UFG%22">Büttner UFG</searchLink>; Institute of Physiological Chemistry, University of Ulm, Ulm, Baden-Württemberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wirth+HL%22">Wirth HL</searchLink>; Institute of Physiological Chemistry, University of Ulm, Ulm, Baden-Württemberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gerstenlauer+M%22">Gerstenlauer M</searchLink>; Institute of Physiological Chemistry, University of Ulm, Ulm, Baden-Württemberg, Germany.<br /><searchLink fieldCode="AU" term="%22Manfras+U%22">Manfras U</searchLink>; Institute of Physiological Chemistry, University of Ulm, Ulm, Baden-Württemberg, Germany.<br /><searchLink fieldCode="AU" term="%22Loidl+R%22">Loidl R</searchLink>; Institute of Physiological Chemistry, University of Ulm, Ulm, Baden-Württemberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bahçeci+D%22">Bahçeci D</searchLink>; Institute of Physiological Chemistry, University of Ulm, Ulm, Baden-Württemberg, Germany.<br /><searchLink fieldCode="AU" term="%22Steiger+K%22">Steiger K</searchLink>; Institute of Pathology, Technical University Munich, Munich, Bayern, Germany.; Comparative Experimental Pathology (CEP), School of Medicine and Health, Technical University Munich, Munich, Bayern, Germany.<br /><searchLink fieldCode="AU" term="%22Metzler+T%22">Metzler T</searchLink>; Institute of Pathology, Technical University Munich, Munich, Bayern, Germany.; Comparative Experimental Pathology (CEP), School of Medicine and Health, Technical University Munich, Munich, Bayern, Germany.<br /><searchLink fieldCode="AU" term="%22Chan+LK%22">Chan LK</searchLink>; Department of Pathology and Molecular Pathology, University Hospital of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tsesmelis+M%22">Tsesmelis M</searchLink>; Single-Cell Sequencing Unit, University of Ulm, Ulm, Baden-Württemberg, Germany. miltiadis.tsesmelis@uni-ulm.de.<br /><searchLink fieldCode="AU" term="%22Wirth+T%22">Wirth T</searchLink>; Institute of Physiological Chemistry, University of Ulm, Ulm, Baden-Württemberg, Germany. thomas.wirth@uni-ulm.de.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 May 27; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 May 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
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              Text: 2026 May 27
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