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Zinc deficiency and sarcopenia define a metabolic frailty phenotype predicting hepatic encephalopathy and early mortality in cirrhosis.

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Title: Zinc deficiency and sarcopenia define a metabolic frailty phenotype predicting hepatic encephalopathy and early mortality in cirrhosis.
Authors: Méndez-Guerrero O; Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Mexico city, 14080, Mexico.; Master's and Doctoral Program in Medical, Dental, and Health Sciences, Universidad Nacional Autonoma de Mexico, México City, Mexico., Carranza-Carrasco A; Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Mexico city, 14080, Mexico., Guerrero-Guerrero R; Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Mexico city, 14080, Mexico., Castillo-Martínez L; Clinical Nutrition Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico., Del Razo-Olvera FM; Research Unit of Metabolic Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico., Juárez-Martínez L; Research Unit of Metabolic Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico., Otero-Otero R; Research Unit of Metabolic Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico., Estanes-Hernández A; Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Mexico city, 14080, Mexico., Clark P; Clinical Epidemiology Unit, Faculty of Medicina UNAM, Hospital Infantil Federico Gómez, Mexico City, Mexico., Aguilar-Salinas CA; Research Unit of Metabolic Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico.; Direction of Nutrition, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico city, Mexico.; Escuela de Medicina y Ciencias de la Salud, Tecnológico de Monterrey, Mexico city, Mexico., Torre A; Department of Gastroenterology, Medical Center ABC, Sur 136 116, Las Américas, Álvaro Obregón, 01120, Ciudad de México, Mexico., Castro-Narro GE; Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Mexico city, 14080, Mexico., Navarro-Alvarez N; Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Mexico city, 14080, Mexico. nalu.navarroa@incmnsz.mx.; Department of Surgery, University of Colorado Anschutz Medical Campus, Denver, CO, USA. nalu.navarroa@incmnsz.mx.
Source: Metabolic brain disease [Metab Brain Dis] 2026 May 28; Vol. 41 (1). Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 8610370 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7365 (Electronic) Linking ISSN: 08857490 NLM ISO Abbreviation: Metab Brain Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Zinc deficiency and sarcopenia define a metabolic frailty phenotype predicting hepatic encephalopathy and early mortality in cirrhosis.
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  Data: <searchLink fieldCode="AU" term="%22Méndez-Guerrero+O%22">Méndez-Guerrero O</searchLink>; Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Mexico city, 14080, Mexico.; Master's and Doctoral Program in Medical, Dental, and Health Sciences, Universidad Nacional Autonoma de Mexico, México City, Mexico.<br /><searchLink fieldCode="AU" term="%22Carranza-Carrasco+A%22">Carranza-Carrasco A</searchLink>; Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Mexico city, 14080, Mexico.<br /><searchLink fieldCode="AU" term="%22Guerrero-Guerrero+R%22">Guerrero-Guerrero R</searchLink>; Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Mexico city, 14080, Mexico.<br /><searchLink fieldCode="AU" term="%22Castillo-Martínez+L%22">Castillo-Martínez L</searchLink>; Clinical Nutrition Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico.<br /><searchLink fieldCode="AU" term="%22Del+Razo-Olvera+FM%22">Del Razo-Olvera FM</searchLink>; Research Unit of Metabolic Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico.<br /><searchLink fieldCode="AU" term="%22Juárez-Martínez+L%22">Juárez-Martínez L</searchLink>; Research Unit of Metabolic Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico.<br /><searchLink fieldCode="AU" term="%22Otero-Otero+R%22">Otero-Otero R</searchLink>; Research Unit of Metabolic Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico.<br /><searchLink fieldCode="AU" term="%22Estanes-Hernández+A%22">Estanes-Hernández A</searchLink>; Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Mexico city, 14080, Mexico.<br /><searchLink fieldCode="AU" term="%22Clark+P%22">Clark P</searchLink>; Clinical Epidemiology Unit, Faculty of Medicina UNAM, Hospital Infantil Federico Gómez, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Aguilar-Salinas+CA%22">Aguilar-Salinas CA</searchLink>; Research Unit of Metabolic Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico.; Direction of Nutrition, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico city, Mexico.; Escuela de Medicina y Ciencias de la Salud, Tecnológico de Monterrey, Mexico city, Mexico.<br /><searchLink fieldCode="AU" term="%22Torre+A%22">Torre A</searchLink>; Department of Gastroenterology, Medical Center ABC, Sur 136 116, Las Américas, Álvaro Obregón, 01120, Ciudad de México, Mexico.<br /><searchLink fieldCode="AU" term="%22Castro-Narro+GE%22">Castro-Narro GE</searchLink>; Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Mexico city, 14080, Mexico.<br /><searchLink fieldCode="AU" term="%22Navarro-Alvarez+N%22">Navarro-Alvarez N</searchLink>; Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Mexico city, 14080, Mexico. nalu.navarroa@incmnsz.mx.; Department of Surgery, University of Colorado Anschutz Medical Campus, Denver, CO, USA. nalu.navarroa@incmnsz.mx.
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