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Tissue scaffold architecture affects implant degradation and bone tissue regeneration: A novel in silico mechanobiological model analysing cell behavior, mechanical stress and degradation kinematics.

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Title: Tissue scaffold architecture affects implant degradation and bone tissue regeneration: A novel in silico mechanobiological model analysing cell behavior, mechanical stress and degradation kinematics.
Authors: Alshammari A; Department of Mechanical and Aerospace Engineering, School of Engineering, University of Manchester, Manchester, United Kingdom.; Department of Mechanical Engineering, University of Ha'il, Ha'il, Kingdom of Saudi Arabia., Alabdah F; Department of Mechanical and Aerospace Engineering, School of Engineering, University of Manchester, Manchester, United Kingdom.; Department of Mechanical Engineering, University of Ha'il, Ha'il, Kingdom of Saudi Arabia., Li L; Department of Mechanical and Aerospace Engineering, School of Engineering, University of Manchester, Manchester, United Kingdom., Cooper G; Department of Mechanical and Aerospace Engineering, School of Engineering, University of Manchester, Manchester, United Kingdom.
Source: PloS one [PLoS One] 2026 May 28; Vol. 21 (5), pp. e0349708. Date of Electronic Publication: 2026 May 28 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Alshammari+A%22">Alshammari A</searchLink>; Department of Mechanical and Aerospace Engineering, School of Engineering, University of Manchester, Manchester, United Kingdom.; Department of Mechanical Engineering, University of Ha'il, Ha'il, Kingdom of Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alabdah+F%22">Alabdah F</searchLink>; Department of Mechanical and Aerospace Engineering, School of Engineering, University of Manchester, Manchester, United Kingdom.; Department of Mechanical Engineering, University of Ha'il, Ha'il, Kingdom of Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Mechanical and Aerospace Engineering, School of Engineering, University of Manchester, Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cooper+G%22">Cooper G</searchLink>; Department of Mechanical and Aerospace Engineering, School of Engineering, University of Manchester, Manchester, United Kingdom.
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        Value: 10.1371/journal.pone.0349708
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