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Revisiting nuclear grade as a high-risk marker for predicting upgrade in ductal carcinoma in situ.

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Title: Revisiting nuclear grade as a high-risk marker for predicting upgrade in ductal carcinoma in situ.
Authors: Ueki Y; Department of Breast Oncology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan., Horimoto Y; Department of Breast Oncology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan; Department of Breast Surgery and Oncology, Tokyo Medical University, 6-7-1 Nishishinjuku, Tokyo, Shinjuku-ku, 1600023, Japan; Department of Human Pathology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan. Electronic address: horimoto.yoshiya.4m@tokyo-med.ac.jp., Harada K; Department of Health Data Science, Tokyo Medical University, 6-7-1 Nishishinjuku, Tokyo, Shinjuku-ku, 1600023, Japan., Ushiyama Y; Department of Breast Oncology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan., Nozaki Y; Department of Breast Oncology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan., Ishizuka Y; Department of Breast Oncology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan., Semba R; Department of Breast Oncology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan., Uenaka N; Department of Breast Surgery and Oncology, Tokyo Medical University, 6-7-1 Nishishinjuku, Tokyo, Shinjuku-ku, 1600023, Japan., Kawate T; Department of Breast Surgery and Oncology, Tokyo Medical University, 6-7-1 Nishishinjuku, Tokyo, Shinjuku-ku, 1600023, Japan., Ushigusa T; Department of Anatomic Pathology, Tokyo Medical University, 6-7-1 Nishishinjuku, Tokyo, Shinjuku-ku, 1600023, Japan., Sato E; Department of Pathology (Medical Research Center), Institute of Medical Science, Tokyo Medical University, 6-7-1 Nishishinjuku, Tokyo, Shinjuku-ku, 1600023, Japan., Onagi H; Department of Human Pathology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan., Hayashi T; Department of Human Pathology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan., Kutomi G; Department of Breast Oncology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan., Ishikawa T; Department of Breast Surgery and Oncology, Tokyo Medical University, 6-7-1 Nishishinjuku, Tokyo, Shinjuku-ku, 1600023, Japan., Yamaguchi R; Breast Center/Department of Diagnostic Pathology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Source: Human pathology [Hum Pathol] 2026 May 27; Vol. 175, pp. 106172. Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article
Journal Info: Publisher: W B Saunders Country of Publication: United States NLM ID: 9421547 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8392 (Electronic) Linking ISSN: 00468177 NLM ISO Abbreviation: Hum Pathol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Ueki+Y%22">Ueki Y</searchLink>; Department of Breast Oncology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan.<br /><searchLink fieldCode="AU" term="%22Horimoto+Y%22">Horimoto Y</searchLink>; Department of Breast Oncology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan; Department of Breast Surgery and Oncology, Tokyo Medical University, 6-7-1 Nishishinjuku, Tokyo, Shinjuku-ku, 1600023, Japan; Department of Human Pathology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan. Electronic address: horimoto.yoshiya.4m@tokyo-med.ac.jp.<br /><searchLink fieldCode="AU" term="%22Harada+K%22">Harada K</searchLink>; Department of Health Data Science, Tokyo Medical University, 6-7-1 Nishishinjuku, Tokyo, Shinjuku-ku, 1600023, Japan.<br /><searchLink fieldCode="AU" term="%22Ushiyama+Y%22">Ushiyama Y</searchLink>; Department of Breast Oncology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan.<br /><searchLink fieldCode="AU" term="%22Nozaki+Y%22">Nozaki Y</searchLink>; Department of Breast Oncology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan.<br /><searchLink fieldCode="AU" term="%22Ishizuka+Y%22">Ishizuka Y</searchLink>; Department of Breast Oncology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan.<br /><searchLink fieldCode="AU" term="%22Semba+R%22">Semba R</searchLink>; Department of Breast Oncology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan.<br /><searchLink fieldCode="AU" term="%22Uenaka+N%22">Uenaka N</searchLink>; Department of Breast Surgery and Oncology, Tokyo Medical University, 6-7-1 Nishishinjuku, Tokyo, Shinjuku-ku, 1600023, Japan.<br /><searchLink fieldCode="AU" term="%22Kawate+T%22">Kawate T</searchLink>; Department of Breast Surgery and Oncology, Tokyo Medical University, 6-7-1 Nishishinjuku, Tokyo, Shinjuku-ku, 1600023, Japan.<br /><searchLink fieldCode="AU" term="%22Ushigusa+T%22">Ushigusa T</searchLink>; Department of Anatomic Pathology, Tokyo Medical University, 6-7-1 Nishishinjuku, Tokyo, Shinjuku-ku, 1600023, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+E%22">Sato E</searchLink>; Department of Pathology (Medical Research Center), Institute of Medical Science, Tokyo Medical University, 6-7-1 Nishishinjuku, Tokyo, Shinjuku-ku, 1600023, Japan.<br /><searchLink fieldCode="AU" term="%22Onagi+H%22">Onagi H</searchLink>; Department of Human Pathology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan.<br /><searchLink fieldCode="AU" term="%22Hayashi+T%22">Hayashi T</searchLink>; Department of Human Pathology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan.<br /><searchLink fieldCode="AU" term="%22Kutomi+G%22">Kutomi G</searchLink>; Department of Breast Oncology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 1130033, Japan.<br /><searchLink fieldCode="AU" term="%22Ishikawa+T%22">Ishikawa T</searchLink>; Department of Breast Surgery and Oncology, Tokyo Medical University, 6-7-1 Nishishinjuku, Tokyo, Shinjuku-ku, 1600023, Japan.<br /><searchLink fieldCode="AU" term="%22Yamaguchi+R%22">Yamaguchi R</searchLink>; Breast Center/Department of Diagnostic Pathology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
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  Data: <searchLink fieldCode="JN" term="%229421547%22">Human pathology</searchLink> [Hum Pathol] 2026 May 27; Vol. 175, pp. 106172. <i>Date of Electronic Publication: </i>2026 May 27.
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