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Multimodal phenotypic classification of generalized anxiety and panic using structural MRI data and psychosocial factors: machine learning results from the German National Cohort (NAKO) study.

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Title: Multimodal phenotypic classification of generalized anxiety and panic using structural MRI data and psychosocial factors: machine learning results from the German National Cohort (NAKO) study.
Authors: Gutzeit J; Department of Psychiatry, Psychosomatic and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany. julian.gutzeit@uni-wuerzburg.de.; Department of Psychology III, University of Würzburg, Würzburg, Germany. julian.gutzeit@uni-wuerzburg.de., Weiß M; Department of Psychiatry, Psychosomatic and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.; Department of Psychology I, University of Würzburg, Würzburg, Germany., Kuhn T; Department of Psychiatry, Psychosomatic and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany., Klinger-König J; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Streit F; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; Hector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; German Center for Mental Health (DZPG), Partner Site Mannheim, Heidelberg - Ulm, Germany., Jockwitz C; Institute for Anatomy I, Medical Faculty & Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany., Brandes B; Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany., Wright MN; Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany.; Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany.; Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Friedrich CM; University Hospital Essen, Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), Essen, Germany.; University of Applied Sciences and Arts Dortmund (FH Dortmund), Department of Computer Science, Dortmund, Germany., Woeckel M; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany., Mikolajczyk R; Institute of Medical Epidemiology, Biometrics and Informatics, Medical Faculty of the Martin-Luther University Halle-Wittenberg, Halle, Wittenberg, Germany.; German Center for Mental Health (DZPG), Site Halle-Jena-Magdeburg, Halle (Saale), Germany.; Center for Intervention and Research on adaptive and maladaptive brain - Circuits underlying mental health (C-I-R-C), Halle-Jena-Magdeburg, Halle (Saale), Germany., Keil T; Institute of Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.; State Institute of Health I, Bavarian Health and Food Safety Authority, Erlangen, Germany., Castell S; Department for Epidemiology, Helmholtz Centre for Infection Research (HZI), Brunswick, Germany., Betker P; Department for Epidemiology, Helmholtz Centre for Infection Research (HZI), Brunswick, Germany., Schlett CL; Department of Diagnostic and Interventional Radiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Bärnighausen TW; Heidelberg Institute of Global Health (HIGH), Medical Faculty and University Hospital, Heidelberg University, Heidelberg, Germany.; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Harvard University, Boston, USA.; Africa Health Research Institute (AHRI), Somkhele and Durban, Durban, South Africa., Bamberg F; Department of Diagnostic and Interventional Radiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Günther M; Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany., Hirsch JG; Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany., Pischon T; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Molecular Epidemiology Research Group, Berlin, Germany.; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC) Biobank Technology Platform, Berlin, Germany.; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Niendorf T; Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Leitzmann MF; Institute for Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany., Bohmann P; Institute for Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.; Department of Neurology, medbo District Hospital and University Hospital of Regensburg, Regensburg, Germany., Wirkner K; Leipzig Research Centre for Civilization Diseases, Leipzig University, Leipzig, Germany., Krist L; Institute of Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin Berlin, Berlin, Germany., Wang Y; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.; Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Pettenkofer School of Public Health, Munich, Germany., Berger K; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Walther S; Department of Psychiatry, Psychosomatic and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Centre for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany., Deckert J; Department of Psychiatry, Psychosomatic and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.; Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany., Caspers S; Institute for Anatomy I, Medical Faculty & Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany., Hein G; Department of Psychiatry, Psychosomatic and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany., Erhardt-Lehmann A; Department of Psychiatry, Psychosomatic and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.; Max Planck Institute of Psychiatry, Munich, Germany.
Source: Translational psychiatry [Transl Psychiatry] 2026 May 28; Vol. 16 (1). Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multimodal phenotypic classification of generalized anxiety and panic using structural MRI data and psychosocial factors: machine learning results from the German National Cohort (NAKO) study.
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  Data: <searchLink fieldCode="AU" term="%22Gutzeit+J%22">Gutzeit J</searchLink>; Department of Psychiatry, Psychosomatic and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany. julian.gutzeit@uni-wuerzburg.de.; Department of Psychology III, University of Würzburg, Würzburg, Germany. julian.gutzeit@uni-wuerzburg.de.<br /><searchLink fieldCode="AU" term="%22Weiß+M%22">Weiß M</searchLink>; Department of Psychiatry, Psychosomatic and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.; Department of Psychology I, University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kuhn+T%22">Kuhn T</searchLink>; Department of Psychiatry, Psychosomatic and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Klinger-König+J%22">Klinger-König J</searchLink>; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Streit+F%22">Streit F</searchLink>; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; Hector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; German Center for Mental Health (DZPG), Partner Site Mannheim, Heidelberg - Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Jockwitz+C%22">Jockwitz C</searchLink>; Institute for Anatomy I, Medical Faculty & Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.<br /><searchLink fieldCode="AU" term="%22Brandes+B%22">Brandes B</searchLink>; Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany.<br /><searchLink fieldCode="AU" term="%22Wright+MN%22">Wright MN</searchLink>; Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany.; Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany.; Department of Public Health, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Friedrich+CM%22">Friedrich CM</searchLink>; University Hospital Essen, Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), Essen, Germany.; University of Applied Sciences and Arts Dortmund (FH Dortmund), Department of Computer Science, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Woeckel+M%22">Woeckel M</searchLink>; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Mikolajczyk+R%22">Mikolajczyk R</searchLink>; Institute of Medical Epidemiology, Biometrics and Informatics, Medical Faculty of the Martin-Luther University Halle-Wittenberg, Halle, Wittenberg, Germany.; German Center for Mental Health (DZPG), Site Halle-Jena-Magdeburg, Halle (Saale), Germany.; Center for Intervention and Research on adaptive and maladaptive brain - Circuits underlying mental health (C-I-R-C), Halle-Jena-Magdeburg, Halle (Saale), Germany.<br /><searchLink fieldCode="AU" term="%22Keil+T%22">Keil T</searchLink>; Institute of Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.; State Institute of Health I, Bavarian Health and Food Safety Authority, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Castell+S%22">Castell S</searchLink>; Department for Epidemiology, Helmholtz Centre for Infection Research (HZI), Brunswick, Germany.<br /><searchLink fieldCode="AU" term="%22Betker+P%22">Betker P</searchLink>; Department for Epidemiology, Helmholtz Centre for Infection Research (HZI), Brunswick, Germany.<br /><searchLink fieldCode="AU" term="%22Schlett+CL%22">Schlett CL</searchLink>; Department of Diagnostic and Interventional Radiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bärnighausen+TW%22">Bärnighausen TW</searchLink>; Heidelberg Institute of Global Health (HIGH), Medical Faculty and University Hospital, Heidelberg University, Heidelberg, Germany.; Department of Global Health and Population, Harvard T.H. 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