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Limitations of the p16-3MR mouse model for detecting and eliminating senescent cells.

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Title: Limitations of the p16-3MR mouse model for detecting and eliminating senescent cells.
Authors: Hori N; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan., Kawamoto S; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan. shimpei.kawamoto@tohoku.ac.jp.; Department of Aging Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, 980-8575, Japan. shimpei.kawamoto@tohoku.ac.jp.; Organization for Advanced Studies, Tohoku University, Sendai, 980-8575, Japan. shimpei.kawamoto@tohoku.ac.jp., Uemura K; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan., Kinugasa-Katayama Y; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan., Okumura Y; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan., Tanaka K; NGS Core Facility, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan., Park JH; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan., Wakita M; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan., Motooka D; NGS Core Facility, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan., Ohtani N; Department of Pathophysiology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, 545-8585, Japan., Hara E; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan. ehara@biken.osaka-u.ac.jp.; Center for Infectious Diseases Education and Research, The University of Osaka, Suita, 565-0871, Japan. ehara@biken.osaka-u.ac.jp.; Immunology Frontier Research Center, The University of Osaka, Suita, 565-0871, Japan. ehara@biken.osaka-u.ac.jp.
Source: EMBO reports [EMBO Rep] 2026 May 28. Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Hori+N%22">Hori N</searchLink>; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Kawamoto+S%22">Kawamoto S</searchLink>; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan. shimpei.kawamoto@tohoku.ac.jp.; Department of Aging Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, 980-8575, Japan. shimpei.kawamoto@tohoku.ac.jp.; Organization for Advanced Studies, Tohoku University, Sendai, 980-8575, Japan. shimpei.kawamoto@tohoku.ac.jp.<br /><searchLink fieldCode="AU" term="%22Uemura+K%22">Uemura K</searchLink>; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Kinugasa-Katayama+Y%22">Kinugasa-Katayama Y</searchLink>; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Okumura+Y%22">Okumura Y</searchLink>; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Tanaka+K%22">Tanaka K</searchLink>; NGS Core Facility, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Park+JH%22">Park JH</searchLink>; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Wakita+M%22">Wakita M</searchLink>; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Motooka+D%22">Motooka D</searchLink>; NGS Core Facility, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Ohtani+N%22">Ohtani N</searchLink>; Department of Pathophysiology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, 545-8585, Japan.<br /><searchLink fieldCode="AU" term="%22Hara+E%22">Hara E</searchLink>; Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, 565-0871, Japan. ehara@biken.osaka-u.ac.jp.; Center for Infectious Diseases Education and Research, The University of Osaka, Suita, 565-0871, Japan. ehara@biken.osaka-u.ac.jp.; Immunology Frontier Research Center, The University of Osaka, Suita, 565-0871, Japan. ehara@biken.osaka-u.ac.jp.
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