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Targeting the Gpr125-Gper1 axis: a novel osteogenic signaling pathway with therapeutic potential against osteoporosis.

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Title: Targeting the Gpr125-Gper1 axis: a novel osteogenic signaling pathway with therapeutic potential against osteoporosis.
Authors: Tang CY; Department of Clinical Nutrition, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China., Han YX; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central, South University, Changsha, Hunan, 410011, China., Wu HX; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central, South University, Changsha, Hunan, 410011, China.; School of Public health, Changsha Medical University, Changsha, Hunan, 410219, China., Jiang HL; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central, South University, Changsha, Hunan, 410011, China., Wen Y; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central, South University, Changsha, Hunan, 410011, China., He Q; Department of Geriatric, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital, Yichang, 443002, P.R. China., Liu Y; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central, South University, Changsha, Hunan, 410011, China., Liu H; Department of Clinical Nutrition, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China., Feng G; Department of Clinical Nutrition, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China., Luo YF; Department of Clinical Nutrition, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China., Wang M; Department of Clinical Nutrition, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China., Ma Y; Department of Geriatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China., Zhou HD; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central, South University, Changsha, Hunan, 410011, China. houdezhou@csu.edu.cn., Liu M; Department of Clinical Nutrition, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China. liuminxy3yy@csu.edu.cn.
Source: Journal of translational medicine [J Transl Med] 2026 May 28. Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting the Gpr125-Gper1 axis: a novel osteogenic signaling pathway with therapeutic potential against osteoporosis.
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  Data: <searchLink fieldCode="AU" term="%22Tang+CY%22">Tang CY</searchLink>; Department of Clinical Nutrition, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.<br /><searchLink fieldCode="AU" term="%22Han+YX%22">Han YX</searchLink>; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central, South University, Changsha, Hunan, 410011, China.<br /><searchLink fieldCode="AU" term="%22Wu+HX%22">Wu HX</searchLink>; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central, South University, Changsha, Hunan, 410011, China.; School of Public health, Changsha Medical University, Changsha, Hunan, 410219, China.<br /><searchLink fieldCode="AU" term="%22Jiang+HL%22">Jiang HL</searchLink>; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central, South University, Changsha, Hunan, 410011, China.<br /><searchLink fieldCode="AU" term="%22Wen+Y%22">Wen Y</searchLink>; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central, South University, Changsha, Hunan, 410011, China.<br /><searchLink fieldCode="AU" term="%22He+Q%22">He Q</searchLink>; Department of Geriatric, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital, Yichang, 443002, P.R. China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central, South University, Changsha, Hunan, 410011, China.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Department of Clinical Nutrition, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.<br /><searchLink fieldCode="AU" term="%22Feng+G%22">Feng G</searchLink>; Department of Clinical Nutrition, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.<br /><searchLink fieldCode="AU" term="%22Luo+YF%22">Luo YF</searchLink>; Department of Clinical Nutrition, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Department of Clinical Nutrition, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; Department of Geriatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.<br /><searchLink fieldCode="AU" term="%22Zhou+HD%22">Zhou HD</searchLink>; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central, South University, Changsha, Hunan, 410011, China. houdezhou@csu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Department of Clinical Nutrition, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China. liuminxy3yy@csu.edu.cn.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190741 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1479-5876 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214795876%22">14795876 </searchLink><i>NLM ISO Abbreviation: </i>J Transl Med <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12967-026-08337-1
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        Text: English
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              Text: 2026 May 28
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