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Ligand-Independent Activation of Notch1 by Cathepsin L Induces CUX1/p16INK4a-Dependent Endothelial Senescence Associated With Atherosclerosis.

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Title: Ligand-Independent Activation of Notch1 by Cathepsin L Induces CUX1/p16INK4a-Dependent Endothelial Senescence Associated With Atherosclerosis.
Authors: Wu Y; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha, China., Lu L; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Yan S; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Du Z; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Jiang D; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Wu T; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha, China., Wu Q; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Liu J; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Ebin J; Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA., Sun W; Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA., Dutta P; Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA., Tan JX; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Alder JK; Division of Pulmonary, Allergy, and Critical Care Medicine, Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Li G; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Division of Cardiology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Source: Aging cell [Aging Cell] 2026 Jun; Vol. 25 (6), pp. e70563.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Ligand-Independent Activation of Notch1 by Cathepsin L Induces CUX1/p16<superscript>INK4a</superscript>-Dependent Endothelial Senescence Associated With Atherosclerosis.
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  Data: <searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Lu+L%22">Lu L</searchLink>; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Yan+S%22">Yan S</searchLink>; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Du+Z%22">Du Z</searchLink>; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+D%22">Jiang D</searchLink>; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Wu+T%22">Wu T</searchLink>; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Wu+Q%22">Wu Q</searchLink>; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Ebin+J%22">Ebin J</searchLink>; Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Sun+W%22">Sun W</searchLink>; Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Dutta+P%22">Dutta P</searchLink>; Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Tan+JX%22">Tan JX</searchLink>; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Alder+JK%22">Alder JK</searchLink>; Division of Pulmonary, Allergy, and Critical Care Medicine, Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Division of Cardiology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
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              Text: 2026 Jun
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