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Prediction of clinical outcomes of advanced cutaneous squamous cell carcinoma to PD-1 inhibition directly from histopathology slides using inferred transcriptomics.

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Title: Prediction of clinical outcomes of advanced cutaneous squamous cell carcinoma to PD-1 inhibition directly from histopathology slides using inferred transcriptomics.
Authors: Chayen B; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Dinstag G; Pangea Biomed Ltd., Tel-Aviv, Israel., Tirosh O; Pangea Biomed Ltd., Tel-Aviv, Israel., Gugel L; Pangea Biomed Ltd., Tel-Aviv, Israel., Beker T; Pangea Biomed Ltd., Tel-Aviv, Israel., Gottlieb T; Pangea Biomed Ltd., Tel-Aviv, Israel., Elia A; Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Pikarsky E; Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.; The Lautenberg Center for Immunology, IMRIC, the Hebrew University of Jerusalem, Jerusalem, Israel., Lotem M; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.; The Lautenberg Center for Immunology, IMRIC, the Hebrew University of Jerusalem, Jerusalem, Israel., Avner M; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.; The Hadassah Cancer Research Institute, Hadassah Hebrew University Medical Center, Jerusalem, Israel.; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Cohen JE; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.; The Hadassah Cancer Research Institute, Hadassah Hebrew University Medical Center, Jerusalem, Israel.; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Aharonov R; Pangea Biomed Ltd., Tel-Aviv, Israel., Popovtzer A; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.; The Hadassah Cancer Research Institute, Hadassah Hebrew University Medical Center, Jerusalem, Israel.; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Arnon J; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.; The Hadassah Cancer Research Institute, Hadassah Hebrew University Medical Center, Jerusalem, Israel.; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Source: Frontiers in immunology [Front Immunol] 2026 May 13; Vol. 17, pp. 1822422. Date of Electronic Publication: 2026 May 13 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Prediction of clinical outcomes of advanced cutaneous squamous cell carcinoma to PD-1 inhibition directly from histopathology slides using inferred transcriptomics.
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  Data: <searchLink fieldCode="AU" term="%22Chayen+B%22">Chayen B</searchLink>; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Dinstag+G%22">Dinstag G</searchLink>; Pangea Biomed Ltd., Tel-Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Tirosh+O%22">Tirosh O</searchLink>; Pangea Biomed Ltd., Tel-Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Gugel+L%22">Gugel L</searchLink>; Pangea Biomed Ltd., Tel-Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Beker+T%22">Beker T</searchLink>; Pangea Biomed Ltd., Tel-Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Gottlieb+T%22">Gottlieb T</searchLink>; Pangea Biomed Ltd., Tel-Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Elia+A%22">Elia A</searchLink>; Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Pikarsky+E%22">Pikarsky E</searchLink>; Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.; The Lautenberg Center for Immunology, IMRIC, the Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Lotem+M%22">Lotem M</searchLink>; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.; The Lautenberg Center for Immunology, IMRIC, the Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Avner+M%22">Avner M</searchLink>; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.; The Hadassah Cancer Research Institute, Hadassah Hebrew University Medical Center, Jerusalem, Israel.; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Cohen+JE%22">Cohen JE</searchLink>; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.; The Hadassah Cancer Research Institute, Hadassah Hebrew University Medical Center, Jerusalem, Israel.; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Aharonov+R%22">Aharonov R</searchLink>; Pangea Biomed Ltd., Tel-Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Popovtzer+A%22">Popovtzer A</searchLink>; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.; The Hadassah Cancer Research Institute, Hadassah Hebrew University Medical Center, Jerusalem, Israel.; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Arnon+J%22">Arnon J</searchLink>; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.; The Hadassah Cancer Research Institute, Hadassah Hebrew University Medical Center, Jerusalem, Israel.; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
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