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SIRT3 activation by oroxylin A phosphate diethyl ester triggers mitochondrial dysfunction and apoptosis in non-small cell lung cancer.

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Title: SIRT3 activation by oroxylin A phosphate diethyl ester triggers mitochondrial dysfunction and apoptosis in non-small cell lung cancer.
Authors: Lee CW; Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi County 61363, Taiwan.; Chronic Diseases and Health Promotion Research Center and Center for smart healthcare and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi County 61363, Taiwan.; Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chiayi County 61363, Taiwan.; Department of Safety Health and Environmental Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan., Lin YF; Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung 41354, Taiwan., Lee KH; School of Pharmacy, Tzu Chi University, Hualien 970374, Taiwan., Sun YS; School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan., Chang TM; School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan., Chi MC; Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi County 61363, Taiwan.; Chronic Diseases and Health Promotion Research Center and Center for smart healthcare and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi County 61363, Taiwan.; Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan., Lin ZC; Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chiayi 61363, Taiwan., Yamamoto A; Child Health Research Centre, The University of Queensland, South Brisbane, Queensland 4101, Australia., Peng KT; Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Puzi City, Chiayi County 61363, Taiwan.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan., Liu JF; School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan.; Translational Medicine Center, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111045, Taiwan.
Source: International journal of biological sciences [Int J Biol Sci] 2026 May 11; Vol. 22 (10), pp. 5283-5300. Date of Electronic Publication: 2026 May 11 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE
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  Data: SIRT3 activation by oroxylin A phosphate diethyl ester triggers mitochondrial dysfunction and apoptosis in non-small cell lung cancer.
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  Data: <searchLink fieldCode="AU" term="%22Lee+CW%22">Lee CW</searchLink>; Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi County 61363, Taiwan.; Chronic Diseases and Health Promotion Research Center and Center for smart healthcare and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi County 61363, Taiwan.; Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chiayi County 61363, Taiwan.; Department of Safety Health and Environmental Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YF%22">Lin YF</searchLink>; Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung 41354, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+KH%22">Lee KH</searchLink>; School of Pharmacy, Tzu Chi University, Hualien 970374, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sun+YS%22">Sun YS</searchLink>; School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+TM%22">Chang TM</searchLink>; School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chi+MC%22">Chi MC</searchLink>; Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi County 61363, Taiwan.; Chronic Diseases and Health Promotion Research Center and Center for smart healthcare and Drug Research and Development, Chang Gung University of Science and Technology, Chiayi County 61363, Taiwan.; Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+ZC%22">Lin ZC</searchLink>; Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chiayi 61363, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+A%22">Yamamoto A</searchLink>; Child Health Research Centre, The University of Queensland, South Brisbane, Queensland 4101, Australia.<br /><searchLink fieldCode="AU" term="%22Peng+KT%22">Peng KT</searchLink>; Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Puzi City, Chiayi County 61363, Taiwan.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+JF%22">Liu JF</searchLink>; School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan.; Translational Medicine Center, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111045, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101235568%22">International journal of biological sciences</searchLink> [Int J Biol Sci] 2026 May 11; Vol. 22 (10), pp. 5283-5300. <i>Date of Electronic Publication: </i>2026 May 11 (<i>Print Publication: </i>2026).
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              Text: 2026 May 11
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