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Structure-based design and synthesis of group A streptogramins that bind to the nascent peptide exit tunnel of the ribosome.

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Title: Structure-based design and synthesis of group A streptogramins that bind to the nascent peptide exit tunnel of the ribosome.
Authors: Lee IJ; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California - San Francisco, San Francisco, California, 94158, United States., Li Q; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California - San Francisco, San Francisco, California, 94158, United States; Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, 201203, China., Raskar T; Department of Bioengineering and Therapeutic Sciences, University of California - San Francisco, San Francisco, California, 94158, United States., Pellegrino J; Department of Bioengineering and Therapeutic Sciences, University of California - San Francisco, San Francisco, California, 94158, United States., Ecker AK; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California - San Francisco, San Francisco, California, 94158, United States; Department of Chemistry, The Scripps Research Institute, La Jolla, California, 92307, United States., Howard SY; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California - San Francisco, San Francisco, California, 94158, United States., Fraser JS; Department of Bioengineering and Therapeutic Sciences, University of California - San Francisco, San Francisco, California, 94158, United States., Seiple IB; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California - San Francisco, San Francisco, California, 94158, United States; Department of Chemistry, The Scripps Research Institute, La Jolla, California, 92307, United States. Electronic address: iseiple@scripps.edu.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 May 09; Vol. 316, pp. 118947. Date of Electronic Publication: 2026 May 09.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structure-based design and synthesis of group A streptogramins that bind to the nascent peptide exit tunnel of the ribosome.
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  Data: <searchLink fieldCode="AU" term="%22Lee+IJ%22">Lee IJ</searchLink>; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California - San Francisco, San Francisco, California, 94158, United States.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California - San Francisco, San Francisco, California, 94158, United States; Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Raskar+T%22">Raskar T</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California - San Francisco, San Francisco, California, 94158, United States.<br /><searchLink fieldCode="AU" term="%22Pellegrino+J%22">Pellegrino J</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California - San Francisco, San Francisco, California, 94158, United States.<br /><searchLink fieldCode="AU" term="%22Ecker+AK%22">Ecker AK</searchLink>; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California - San Francisco, San Francisco, California, 94158, United States; Department of Chemistry, The Scripps Research Institute, La Jolla, California, 92307, United States.<br /><searchLink fieldCode="AU" term="%22Howard+SY%22">Howard SY</searchLink>; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California - San Francisco, San Francisco, California, 94158, United States.<br /><searchLink fieldCode="AU" term="%22Fraser+JS%22">Fraser JS</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California - San Francisco, San Francisco, California, 94158, United States.<br /><searchLink fieldCode="AU" term="%22Seiple+IB%22">Seiple IB</searchLink>; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California - San Francisco, San Francisco, California, 94158, United States; Department of Chemistry, The Scripps Research Institute, La Jolla, California, 92307, United States. Electronic address: iseiple@scripps.edu.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ejmech.2026.118947
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        Text: English
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              Text: 2026 May 09
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