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Efficacy and safety of the CD40 ligand inhibitor dapirolizumab pegol in systemic lupus erythematosus (PHOENYCS GO): a randomised, double-blind, placebo-controlled, phase 3 trial.

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Title: Efficacy and safety of the CD40 ligand inhibitor dapirolizumab pegol in systemic lupus erythematosus (PHOENYCS GO): a randomised, double-blind, placebo-controlled, phase 3 trial.
Authors: Clowse MEB; Division of Rheumatology and Immunology, Duke University, Durham, NC, USA. Electronic address: megan.clowse@duke.edu., Isenberg DA; Department of Ageing, Rheumatology and Regenerative Medicine, Division of Medicine, University College London, London, UK., Merrill JT; Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Dörner T; Department of Medicine/Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany., Petri M; Johns Hopkins University School of Medicine, Baltimore, MD, USA., Vital EM; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Morand EF; Centre for Inflammatory Diseases, Monash University and Monash Health, Melbourne, VIC, Australia., Touma Z; Division of Rheumatology, University of Toronto Lupus Clinic, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada., Askanase AD; Columbia University Medical Center, New York, NY, USA., Ioannou Y; UCB, Slough, UK., Brookes S; Biogen, Maidenhead, UK., Gaiha-Rohrbach J; Biogen, Cambridge, MA, USA., Koch ED; UCB, Monheim am Rhein, Germany., Zibian N; UCB, Colombes, France., Martin C; UCB, Slough, UK., Jimenez T; UCB, Raleigh, NC, USA., Nelde A; Biogen, Baar, Switzerland., Stach C; UCB, Monheim am Rhein, Germany.
Corporate Authors: PHOENYCS GO Study Investigators’ Group
Source: Lancet (London, England) [Lancet] 2026 Jun 06; Vol. 407 (10545), pp. 2291-2304. Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy and safety of the CD40 ligand inhibitor dapirolizumab pegol in systemic lupus erythematosus (PHOENYCS GO): a randomised, double-blind, placebo-controlled, phase 3 trial.
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  Data: <searchLink fieldCode="AU" term="%22Clowse+MEB%22">Clowse MEB</searchLink>; Division of Rheumatology and Immunology, Duke University, Durham, NC, USA. Electronic address: megan.clowse@duke.edu.<br /><searchLink fieldCode="AU" term="%22Isenberg+DA%22">Isenberg DA</searchLink>; Department of Ageing, Rheumatology and Regenerative Medicine, Division of Medicine, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Merrill+JT%22">Merrill JT</searchLink>; Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Dörner+T%22">Dörner T</searchLink>; Department of Medicine/Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Petri+M%22">Petri M</searchLink>; Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Vital+EM%22">Vital EM</searchLink>; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Morand+EF%22">Morand EF</searchLink>; Centre for Inflammatory Diseases, Monash University and Monash Health, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Touma+Z%22">Touma Z</searchLink>; Division of Rheumatology, University of Toronto Lupus Clinic, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Askanase+AD%22">Askanase AD</searchLink>; Columbia University Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ioannou+Y%22">Ioannou Y</searchLink>; UCB, Slough, UK.<br /><searchLink fieldCode="AU" term="%22Brookes+S%22">Brookes S</searchLink>; Biogen, Maidenhead, UK.<br /><searchLink fieldCode="AU" term="%22Gaiha-Rohrbach+J%22">Gaiha-Rohrbach J</searchLink>; Biogen, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Koch+ED%22">Koch ED</searchLink>; UCB, Monheim am Rhein, Germany.<br /><searchLink fieldCode="AU" term="%22Zibian+N%22">Zibian N</searchLink>; UCB, Colombes, France.<br /><searchLink fieldCode="AU" term="%22Martin+C%22">Martin C</searchLink>; UCB, Slough, UK.<br /><searchLink fieldCode="AU" term="%22Jimenez+T%22">Jimenez T</searchLink>; UCB, Raleigh, NC, USA.<br /><searchLink fieldCode="AU" term="%22Nelde+A%22">Nelde A</searchLink>; Biogen, Baar, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stach+C%22">Stach C</searchLink>; UCB, Monheim am Rhein, Germany.
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  Data: <searchLink fieldCode="JN" term="%222985213R%22">Lancet (London, England)</searchLink> [Lancet] 2026 Jun 06; Vol. 407 (10545), pp. 2291-2304. <i>Date of Electronic Publication: </i>2026 May 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985213R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-547X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201406736%22">01406736 </searchLink><i>NLM ISO Abbreviation: </i>Lancet <i>Subsets: </i>MEDLINE
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