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Multifactorial sheltering in peristromal niches shapes in vivo responses of lung cancers to targeted therapies.

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Title: Multifactorial sheltering in peristromal niches shapes in vivo responses of lung cancers to targeted therapies.
Authors: Desai B; Department of Tumor Microenvironment and Metastasis, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.; Cancer Biology Ph.D. Program, University of South Florida, Tampa, FL, USA., Miti T; Department of Integrated Mathematical Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Prabhakaran S; Department of Integrated Mathematical Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Miroshnychenko D; Department of Tumor Microenvironment and Metastasis, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Kumar P; Department of Tumor Microenvironment and Metastasis, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Henry M; Department of Tumor Microenvironment and Metastasis, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Marusyk V; Department of Tumor Microenvironment and Metastasis, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Siqueira NSN; Department of Tumor Microenvironment and Metastasis, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Gatenbee C; Department of Integrated Mathematical Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Ozakinci H; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Bui M; Department of Machine Learning, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Boyle TA; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.; Department of Machine Learning, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Scott J; Department of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH, USA., Altrock PM; Department of Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel University, Kiel, Germany., Pellini B; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.; Department of Thoracic Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, USA., Haura E; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Anderson ARA; Department of Integrated Mathematical Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Basanta D; Department of Integrated Mathematical Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Marusyk A; Department of Tumor Microenvironment and Metastasis, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. andriy.marusyk@moffitt.org.; Department of Molecular Medicine, University of South Florida, Tampa, FL, USA. andriy.marusyk@moffitt.org.
Source: Nature communications [Nat Commun] 2026 May 29. Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Desai+B%22">Desai B</searchLink>; Department of Tumor Microenvironment and Metastasis, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.; Cancer Biology Ph.D. Program, University of South Florida, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Miti+T%22">Miti T</searchLink>; Department of Integrated Mathematical Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Prabhakaran+S%22">Prabhakaran S</searchLink>; Department of Integrated Mathematical Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Miroshnychenko+D%22">Miroshnychenko D</searchLink>; Department of Tumor Microenvironment and Metastasis, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+P%22">Kumar P</searchLink>; Department of Tumor Microenvironment and Metastasis, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Henry+M%22">Henry M</searchLink>; Department of Tumor Microenvironment and Metastasis, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Marusyk+V%22">Marusyk V</searchLink>; Department of Tumor Microenvironment and Metastasis, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Siqueira+NSN%22">Siqueira NSN</searchLink>; Department of Tumor Microenvironment and Metastasis, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Gatenbee+C%22">Gatenbee C</searchLink>; Department of Integrated Mathematical Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Ozakinci+H%22">Ozakinci H</searchLink>; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Bui+M%22">Bui M</searchLink>; Department of Machine Learning, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Boyle+TA%22">Boyle TA</searchLink>; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.; Department of Machine Learning, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Scott+J%22">Scott J</searchLink>; Department of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Altrock+PM%22">Altrock PM</searchLink>; Department of Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Pellini+B%22">Pellini B</searchLink>; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.; Department of Thoracic Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Haura+E%22">Haura E</searchLink>; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+ARA%22">Anderson ARA</searchLink>; Department of Integrated Mathematical Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Basanta+D%22">Basanta D</searchLink>; Department of Integrated Mathematical Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Marusyk+A%22">Marusyk A</searchLink>; Department of Tumor Microenvironment and Metastasis, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. andriy.marusyk@moffitt.org.; Department of Molecular Medicine, University of South Florida, Tampa, FL, USA. andriy.marusyk@moffitt.org.
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