View in EDS

Neuroproteasomes regulate endogenous tau paired helical filament formation in an APOE genotype- and age-dependent manner.

Saved in:
Bibliographic Details
Title: Neuroproteasomes regulate endogenous tau paired helical filament formation in an APOE genotype- and age-dependent manner.
Authors: Paradise V; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Konrad-Vicario KD; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Nguyen C; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Sharif NA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Wang X; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Mukim RD; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Sabu M; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Corjuc BT; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Bafia J; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA., Fu J; Program in Medical Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Maldonado GC; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Strickland M; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA., Grauman SL; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Figueroa H; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Hyman BT; Alzheimer Research Unit of the MassGeneral Institute for Neurodegenerative Disease, Department of Neurology of the Massachusetts General Hospital, and Harvard Medical School, Charlestown, MA, USA., Holtzman DM; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA., Nuriel T; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Ramachandran KV; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA. kvr2113@cumc.columbia.edu.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. kvr2113@cumc.columbia.edu.; Department of Neuroscience, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. kvr2113@cumc.columbia.edu.
Source: Nature neuroscience [Nat Neurosci] 2026 May 29. Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42215643
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Neuroproteasomes regulate endogenous tau paired helical filament formation in an APOE genotype- and age-dependent manner.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Paradise+V%22">Paradise V</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Konrad-Vicario+KD%22">Konrad-Vicario KD</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+C%22">Nguyen C</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sharif+NA%22">Sharif NA</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mukim+RD%22">Mukim RD</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sabu+M%22">Sabu M</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Corjuc+BT%22">Corjuc BT</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bafia+J%22">Bafia J</searchLink>; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fu+J%22">Fu J</searchLink>; Program in Medical Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Maldonado+GC%22">Maldonado GC</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Strickland+M%22">Strickland M</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Grauman+SL%22">Grauman SL</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Figueroa+H%22">Figueroa H</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hyman+BT%22">Hyman BT</searchLink>; Alzheimer Research Unit of the MassGeneral Institute for Neurodegenerative Disease, Department of Neurology of the Massachusetts General Hospital, and Harvard Medical School, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Holtzman+DM%22">Holtzman DM</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Nuriel+T%22">Nuriel T</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ramachandran+KV%22">Ramachandran KV</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA. kvr2113@cumc.columbia.edu.; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. kvr2113@cumc.columbia.edu.; Department of Neuroscience, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. kvr2113@cumc.columbia.edu.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229809671%22">Nature neuroscience</searchLink> [Nat Neurosci] 2026 May 29. <i>Date of Electronic Publication: </i>2026 May 29.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9809671 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-1726 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210976256%22">10976256 </searchLink><i>NLM ISO Abbreviation: </i>Nat Neurosci <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42215643
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41593-026-02297-x
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Neuroproteasomes regulate endogenous tau paired helical filament formation in an APOE genotype- and age-dependent manner.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Paradise V
      – PersonEntity:
          Name:
            NameFull: Konrad-Vicario KD
      – PersonEntity:
          Name:
            NameFull: Nguyen C
      – PersonEntity:
          Name:
            NameFull: Sharif NA
      – PersonEntity:
          Name:
            NameFull: Wang X
      – PersonEntity:
          Name:
            NameFull: Mukim RD
      – PersonEntity:
          Name:
            NameFull: Sabu M
      – PersonEntity:
          Name:
            NameFull: Corjuc BT
      – PersonEntity:
          Name:
            NameFull: Bafia J
      – PersonEntity:
          Name:
            NameFull: Fu J
      – PersonEntity:
          Name:
            NameFull: Maldonado GC
      – PersonEntity:
          Name:
            NameFull: Strickland M
      – PersonEntity:
          Name:
            NameFull: Grauman SL
      – PersonEntity:
          Name:
            NameFull: Figueroa H
      – PersonEntity:
          Name:
            NameFull: Hyman BT
      – PersonEntity:
          Name:
            NameFull: Holtzman DM
      – PersonEntity:
          Name:
            NameFull: Nuriel T
      – PersonEntity:
          Name:
            NameFull: Ramachandran KV
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 29
              M: 05
              Text: 2026 May 29
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1546-1726
          Titles:
            – TitleFull: Nature neuroscience
              Type: main
ResultId 1