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Real-world data for a CDK4/6 inhibitor, palbociclib, as 1st- or 2nd-line therapy in HR+/HER2- metastatic breast cancer: a multicenter prospective cohort study.

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Title: Real-world data for a CDK4/6 inhibitor, palbociclib, as 1st- or 2nd-line therapy in HR+/HER2- metastatic breast cancer: a multicenter prospective cohort study.
Authors: Ishikawa T; Department of Breast Surgical Oncology, Tokyo Medical University, Tokyo, Japan. tishik55@gmail.com., Uemura Y; Biostatistics Section, Department of Data Science, Center for Clinical Sciences, Japan Institute for Health Security, Tokyo, Japan., Seki H; Department of Breast Surgery, NHO Tokyo Medical Center, Tokyo, Japan., Kitada M; Department of Breast Disease Center, Asahikawa Medical University Hospital, Asahikawa, Hokkaido, Japan., Saito T; Department of Breast Surgery, Saitama Red Cross Hospital, Saitama, Japan., Yamada K; Department of Breast Surgical Oncology, Tokyo Medical University, Tokyo, Japan., Takao S; Department of Breast Surgery, Konan Medical Center, Kobe, Hyogo, Japan., Takabatake D; Department of Breast Surgery, NHO Shikoku Cancer Center, Matsuyama, Ehime, Japan., Yokota T; Department of Breast and Endocrine Surgery, NHO Shibukawa Medical Center, Shibukawa, Gunma, Japan., Kitahara M; Department of Breast Surgery, Ibaraki Prefectural Center Hospital and Cancer Center, Ibaraki, Japan., Kikawa Y; Department of Breast Surgery, Kansai Medical University, Osaka, Japan., Yamada A; Department of Breast Surgery, Yokohama City University Hospital, Kanagawa, Kanagawa, Japan., Toh U; Department of Surgery, Kurume University School of Medicine, Fukuoka, Japan., Nishimura H; Department of Breast Surgery, Nagano Municipal Hospital, Nagano, Japan., Kaise H; Department of Breast Surgical Oncology, Tokyo Medical University, Tokyo, Japan., Yamagami K; Department of Breast Surgery, Shinko Hospital, Kobe, Hyogo, Japan., Nishimura R; Department of Breast Surgery, Sagara Hospital Miyazaki, Miyazaki, Japan., Taira N; Department of Breast and Thyroid Surgery, Kawasaki Medical University, Okayama, Japan., Narui K; Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan., Mukai H; Department of Medical Oncology, National Cancer Center Hospital East, Chiba, Japan.
Source: Breast cancer research : BCR [Breast Cancer Res] 2026 May 29. Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100927353 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1465-542X (Electronic) Linking ISSN: 14655411 NLM ISO Abbreviation: Breast Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Real-world data for a CDK4/6 inhibitor, palbociclib, as 1st- or 2nd-line therapy in HR+/HER2- metastatic breast cancer: a multicenter prospective cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Ishikawa+T%22">Ishikawa T</searchLink>; Department of Breast Surgical Oncology, Tokyo Medical University, Tokyo, Japan. tishik55@gmail.com.<br /><searchLink fieldCode="AU" term="%22Uemura+Y%22">Uemura Y</searchLink>; Biostatistics Section, Department of Data Science, Center for Clinical Sciences, Japan Institute for Health Security, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Seki+H%22">Seki H</searchLink>; Department of Breast Surgery, NHO Tokyo Medical Center, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kitada+M%22">Kitada M</searchLink>; Department of Breast Disease Center, Asahikawa Medical University Hospital, Asahikawa, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Saito+T%22">Saito T</searchLink>; Department of Breast Surgery, Saitama Red Cross Hospital, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Yamada+K%22">Yamada K</searchLink>; Department of Breast Surgical Oncology, Tokyo Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Takao+S%22">Takao S</searchLink>; Department of Breast Surgery, Konan Medical Center, Kobe, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Takabatake+D%22">Takabatake D</searchLink>; Department of Breast Surgery, NHO Shikoku Cancer Center, Matsuyama, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Yokota+T%22">Yokota T</searchLink>; Department of Breast and Endocrine Surgery, NHO Shibukawa Medical Center, Shibukawa, Gunma, Japan.<br /><searchLink fieldCode="AU" term="%22Kitahara+M%22">Kitahara M</searchLink>; Department of Breast Surgery, Ibaraki Prefectural Center Hospital and Cancer Center, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Kikawa+Y%22">Kikawa Y</searchLink>; Department of Breast Surgery, Kansai Medical University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Yamada+A%22">Yamada A</searchLink>; Department of Breast Surgery, Yokohama City University Hospital, Kanagawa, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Toh+U%22">Toh U</searchLink>; Department of Surgery, Kurume University School of Medicine, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Nishimura+H%22">Nishimura H</searchLink>; Department of Breast Surgery, Nagano Municipal Hospital, Nagano, Japan.<br /><searchLink fieldCode="AU" term="%22Kaise+H%22">Kaise H</searchLink>; Department of Breast Surgical Oncology, Tokyo Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yamagami+K%22">Yamagami K</searchLink>; Department of Breast Surgery, Shinko Hospital, Kobe, Hyogo, Japan.<br /><searchLink fieldCode="AU" term="%22Nishimura+R%22">Nishimura R</searchLink>; Department of Breast Surgery, Sagara Hospital Miyazaki, Miyazaki, Japan.<br /><searchLink fieldCode="AU" term="%22Taira+N%22">Taira N</searchLink>; Department of Breast and Thyroid Surgery, Kawasaki Medical University, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Narui+K%22">Narui K</searchLink>; Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Mukai+H%22">Mukai H</searchLink>; Department of Medical Oncology, National Cancer Center Hospital East, Chiba, Japan.
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  Data: <searchLink fieldCode="JN" term="%22100927353%22">Breast cancer research : BCR</searchLink> [Breast Cancer Res] 2026 May 29. <i>Date of Electronic Publication: </i>2026 May 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central+Ltd%22">BioMed Central Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100927353 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1465-542X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214655411%22">14655411 </searchLink><i>NLM ISO Abbreviation: </i>Breast Cancer Res <i>Subsets: </i>MEDLINE
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